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The Recent Status of Multidrug- and Extensively Drug-Resistant Tuberculosis in Korea

Tuberculosis & Respiratory Diseases / Tuberculosis & Respiratory Diseases,
2010, v.68 no.3, pp.146-154














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Abstract

Background: The increasing incidence of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) has become a serious worldwide problem. However, there is insufficient data regarding the current status of MDR-TB and XDR-TB in Korea. This study examined the recent status of MDR- and XDR-TB using the data from 7 laboratories, in which almost all drug susceptibility tests (DST) for Mycobacterium tuberculosis were performed. Methods: The patients’ identification data and DST results were collected from all 7 laboratories from 2001 to 2006 and the number of patients with MDR-TB and XDR-TB were calculated. Results: The number of DSTs was 140,638 for 6 years with an increasing incidence each year (p<0.001). The number of DST with MDR results was 18,510 and personal identifying information was obtained in 16,640 (89.9%) tests. The number of MDR-TB patients from 2001 to 2006 was 2,329, 2,496, 2,374, 2,300, 2,354, and 2,178, respectively, when counting the duplications in a year as one patient. The number of MDR-TB patients when counting the duplications in 6 years as one patient was 2,281, 1,977, 1,620, 1,446, 1,512, and 1,373, respectively. When the same method was adopted, the number of XDR-TB patients was 191, 238, 282, 260, 272, and 264, respectively, and 189, 150, 130, 90, 122, and 110 patients, respectively. Conclusion: Despite the national efforts to control TB, there are still a large number of MDR- and XDR-TB patients in Korea.

keywords
Tuberculosis, Multidrug-Resistant, Extensively Drug-Resistant Tuberculosis, Microbial Sensitivity Tests, Korea, Tuberculosis, Multidrug-Resistant, Extensively Drug-Resistant Tuberculosis, Microbial Sensitivity Tests, Korea

Reference

1.

1. Pablos-Méndez A, Raviglione MC, Laszlo A, Binkin N,Rieder HL, Bustreo F, et al. Global surveillance for antituberculosis-drug resistance, 1994-1997: World Health Organization-International Union against Tuberculosis and Lung Disease Working Group on Anti-Tuberculosis Drug Resistance Surveillance. N Engl J Med 1998;338:1641-9.

2.

2. Gandhi NR, Moll A, Sturm AW, Pawinski R, Govender T, Lalloo U, et al. Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa.Lancet 2006;368:1575-80.

3.

3. Velayati AA, Masjedi MR, Farnia P, Tabarsi P, Ghanavi J, Ziazarifi AH, et al. Emergence of new forms of totally drug-resistant tuberculosis bacilli: super extensively drugresistant tuberculosis or totally drug-resistant strains in Iran. Chest 2009;136:420-5.

4.

4. Bai GH, Park YK, Choi YW, Bai JI, Kim HJ, Chang CL,et al. Trend of anti-tuberculosis drug resistance in Korea, 1994-2004. Int J Tuberc Lung Dis 2007;11:571-6.

5.

5. Bae GH. National tuberculosis control program in Korea: actions for TB elimination. Commun Dis Mon Rep 2006;17:1-10.

6.

6. Jeon D, Shin D, Kang H, Sung N, Kweon K, Shin E,et al. Trend of multidrug and extensively drug resistant tuberculosis in a tuberculosis referral hospital, 2001∼2005. Tuberc Respir Dis 2008;64:187-93.

7.

7. Kim BJ, Lee IH, Lee DH, Bai GH, Kong SJ, Lee SH,et al. The current status of multidrug-resistant tuberculosis in Korea. Tuberc Respir Dis 2006;60:404-11.

8.

8. Case definition for extensively drug-resistant tuberculosis.Wkly Epidemiol Rec 2006;81:408.

9.

9. Wright A, Zignol M, Van Deun A, Falzon D, Gerdes SR, Feldman K, et al. Epidemiology of antituberculosis drug resistance 2002-07: an updated analysis of the Global Project on Anti-Tuberculosis Drug Resistance Surveillance. Lancet 2009;373:1861-73.

10.

10. World Health Organization. Global map and information on XDR-TB: countries that had reported at least one XDR-TB case by September 2009 [internet]. Geneva:World Health Organization; 2009 [cited 2009 Dec 20].Available from: http://www.who.int/tb/challenges/xdr/xdr_map_sep09.pdf.

11.

11. Centers for Disease Control and Prevention. Emergence of Mycobacterium tuberculosis with extensive resistance to second-line drugs: worldwide, 2000-2004. MMWR Morb Mortal Wkly Rep 2006;55:301-5.

12.

12. Kim DH, Kim HJ, Park SK, Kong SJ, Kim YS, Kim TH,et al. Treatment outcomes and long-term survival in patients with extensively drug-resistant tuberculosis.Am J Respir Crit Care Med 2008;178:1075-82.

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