바로가기메뉴

본문 바로가기 주메뉴 바로가기

Clinical Characteristics of Slowly Growing Lung Cancer: 6 Case- Series Evaluation

Tuberculosis & Respiratory Diseases / Tuberculosis & Respiratory Diseases,
2010, v.68 no.3, pp.180-184












  • Downloaded
  • Viewed

Abstract

Slowly growing lung cancers are quite rare and the leading cause of length time bias and over-diagnosis bias in lung cancer screening. We report 6 cases of slowly growing lung cancer in a tertiary hospital between January 1999 and December 2008. The clinical characteristics of these 6 cases with slowly growing lung cancer were examined. The median age at diagnosis was 68 years (range, 49∼72), and 5 patients (83%) were female. The most common histology type was adenocarcinoma (83%). After excluding two patients who showed no change in the tumor size, the median tumor doubling time was 189 months (range, 86∼387). The proportion of patients with slowly growing lung cancer appears to be particularly large in women, especially among patients with adenocarcinoma. Our experience shows that slowly growly lung cancers are more heterogeneous and diverse.

keywords
Lung Neoplasm, Adenocarcinoma, Slow Growth

Reference

1.

1. Molina JR, Adjei AA, Jett JR. Advances in chemotherapy of non-small cell lung cancer. Chest 2006;130:1211-9.

2.

2. Patz EF Jr, Goodman PC, Bepler G. Screening for lung cancer. N Engl J Med 2000;343:1627-33.

3.

3. Jeong HC, Lee SY, Oh YH, In KH, Kim HG, Yoo SH.An adenocarcinoma of lung with unusual very slow growth: a case report. J Lung Cancer 2006;5:51-4.

4.

4. Kwon KD, Kim JH, Kim DY, Choi MH, Choi JH, Shin DW, et al. A case of adenocarcinoma presenting a solitary pulmonary nodule that grows slowly over 10 years. Tuberc Respir Dis 2008;64:318-23.

5.

5. Yoon BK, Kim EJ, Kim DI, Lee KH, Ryu JS, Kwak SM,et al. A case of adenocarcinoma presenting a solitary pulmonary nodule that showed no growth over 4 years. Tuberc Respir Dis 2005;59:326-9.

6.

6. Detterbeck FC, Gibson CJ. Turning gray: the natural history of lung cancer over time. J Thorac Oncol 2008;3:781-92

7.

7. Hasegawa M, Sone S, Takashima S, Li F, Yang ZG,Maruyama Y, et al. Growth rate of small lung cancers detected on mass CT screening. Br J Radiol 2000;73:1252-9.

8.

8. Lindell RM, Hartman TE, Swensen SJ, Jett JR, Midthun DE, Tazelaar HD, et al. Five-year lung cancer screening experience: CT appearance, growth rate, location, and histologic features of 61 lung cancers. Radiology 2007;242:555-62.

9.

9. Hillerdal G. Indolent lung cancers: time for a paradigm shift: a review. J Thorac Oncol 2008;3:208-11.

10.

10. Goldstraw P, Crowley J, Chansky K, Giroux DJ,Groome PA, Rami-Porta R, et al. The IASLC Lung Cancer Staging Project: proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM Classification of malignant tumours.J Thorac Oncol 2007;2:706-14.

11.

11. Joseph WL, Morton DL, Adkins PC. Prognostic significance of tumor doubling time in evaluating operability in pulmonary metastatic disease. J Thorac Cardiovasc Surg 1971;61:23-32.

12.

12. Aoki T, Nakata H, Watanabe H, Nakamura K, Kasai T,Hashimoto H, et al. Evolution of peripheral lung adenocarcinomas:CT findings correlated with histology and tumor doubling time. AJR Am J Roentgenol 2000;174:763-8.

13.

13. Marcus PM, Bergstralh EJ, Fagerstrom RM, Williams DE,Fontana R, Taylor WF, et al. Lung cancer mortality in the Mayo Lung Project: impact of extended follow-up.J Natl Cancer Inst 2000;92:1308-16.

14.

14. Bach PB, Jett JR, Pastorino U, Tockman MS, Swensen SJ, Begg CB. Computed tomography screening and lung cancer outcomes. JAMA 2007;297:953-61.

15.

15. Bepler G, Goodridge Carney D, Djulbegovic B, Clark RA, Tockman M. A systematic review and lessons learned from early lung cancer detection trials using low-dose computed tomography of the chest. Cancer Control 2003;10:306-14.

Tuberculosis & Respiratory Diseases