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Tuberculosis & Respiratory Diseases

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Vol.69 No.2
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A Case of Multiple Pulmonary Plasmacytomas after Complete Remission of Multiple Myeloma

Tuberculosis & Respiratory Diseases / Tuberculosis & Respiratory Diseases,
2010, v.69 no.2, pp.129-133



& (2010). A Case of Multiple Pulmonary Plasmacytomas after Complete Remission of Multiple Myeloma. Tuberculosis & Respiratory Diseases, 69(2), 129-133.
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Abstract

Extramedullary plasmacytoma (EMP) is a rare disorder that typically occurs in the upper airway. Although the condition rarely arises in the lungs, a few cases have been reported. Here, we report a case of pulmonary plasmacytoma in 66-year-old man, who had been treated with VAD (vincrestine, adriamycin, dexamethasone) chemotherapy for multiple myeloma. The patient had been declared clear of multiple myeloma after 4 cycles of chemotherapy. Three months later, the patient had multiple masses visible on computed tomography (CT) and on positron emission tomography-computed tomography (PET-CT) with hot uptake. Subsequent studies using CT-guided needle biopsy and immunohistochemical stain showed pulmonary plasmacytoma. Bone marrow biopsy, serum, and urine M protein tests were repeated, showing no evidence of multiple myeloma. Pulmonary plasmacytomas, as extramedullary plasmacytomas, were considered an isolated manifestation of multiple myeloma recurrence. We treated the patient with concurrent chemoradiotherapy and the pulmonary plasmacytomas regressed dramatically.

keywords
Multiple Myeloma, Plasmacytoma, Lung

Reference

1.

1. Corwin J, Lindberg RD. Solitary plasmacytoma of bone vs. extramedullary plasmacytoma and their relationship to multiple myeloma. Cancer 1979;43:1007-13.

2.

2. Woodruff RK, Whittle JM, Malpas JS. Solitary plasmacytoma.I: Extramedullary soft tissue plasmacytoma. Cancer 1979;43:2340-3.

3.

3. Knowling MA, Harwood AR, Bergsagel DE. Comparison of extramedullary plasmacytomas with solitary and multiple plasma cell tumors of bone. J Clin Oncol 1983;1:255-62.

4.

4. Thoennissen NH, Schliemann C, Hungermann D, Bremer J, Juergens KU, Semik M, et al. Solitary plasmacytoma of the lung with coexisting sarcoid-like lesions.Ann Hematol 2008;87:417-20.

5.

5. Koss MN, Hochholzer L, Moran CA, Frizzera G. Pulmonary plasmacytomas: a clinicopathologic and immunohistochemical study of five cases. Ann Diagn Pathol 1998;2:1-11.

6.

6. Goździuk K, Kedra M, Rybojad P, Sagan D. A rare case of solitary plasmacytoma mimicking a primary lung tumor. Ann Thorac Surg 2009;87:e25-6.

7.

7. Hayes-Lattin B, Blanke CD, Deloughery TG. Pulmonary and intracerebral plasmacytomas in a patient without multiple myeloma: a case report. Am J Hematol 2003;73:131-4.

8.

8. Adam Z, Bolcák K, Stanícek J, Pour L, Hájek R, Krejcí M, et al. The value of fluorodeoxyglucose positron emission tomography in multiple myeloma. Vnitr Lek 2006;52:207-14.

9.

9. Luh SP, Lai YS, Tsai CH, Tsao TC. Extramedullary plasmacytoma (EMP): report of a case manifested as a mediastinal mass and multiple pulmonary nodules and review of literature. World J Surg Oncol 2007;5:123.

10.

10. Kim SH, Kim ES, Hur JW, Lee JH, Chang SH, Kim YS,et al. A case of relapsed renal plasmacytoma after complete remission of multiple myeloma. Korean J Med 2003;64:114-8.

11.

11. Vande Broek I, Stadnik T, Meurs A, Maes J, Van Camp B, Schots R. Extramedullary plasmacytoma of the cavernous sinus. Leuk Lymphoma 2002;43:1691-3.

12.

12. Liebross RH, Ha CS, Cox JD, Weber D, Delasalle K,Alexanian R. Clinical course of solitary extramedullary plasmacytoma. Radiother Oncol 1999;52:245-9.

13.

13. Mayr NA, Wen BC, Hussey DH, Burns CP, Staples JJ,Doornbos JF, et al. The role of radiation therapy in the treatment of solitary plasmacytomas. Radiother Oncol 1990;17:293-303.

14.

14. Creach KM, Foote RL, Neben-Wittich MA, Kyle RA.Radiotherapy for extramedullary plasmacytoma of the head and neck. Int J Radiat Oncol Biol Phys 2009;73:789-94.

15.

15. Dimopoulos MA, Kiamouris C, Moulopoulos LA. Solitary plasmacytoma of bone and extramedullary plasmacytoma.Hematol Oncol Clin North Am 1999;13:1249-57.

16.

16. Wise JN, Schaefer RF, Read RC. Primary pulmonary plasmacytoma: a case report. Chest 2001;120:1405-7.

17.

17. Wang J, Pandha HS, Treleaven J, Powles R. Metastatic extramedullary plasmacytoma of the lung. Leuk Lymphoma 1999;35:423-5.

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