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Tuberculosis & Respiratory Diseases

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Vol.71 No.5
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Respiratory Virus Detection Rate in Patients with Severe or Atypical Community-acquired Pneumonia

Tuberculosis & Respiratory Diseases / Tuberculosis & Respiratory Diseases,
2011, v.71 no.5, pp.335-340












& (2011). Respiratory Virus Detection Rate in Patients with Severe or Atypical Community-acquired Pneumonia. Tuberculosis & Respiratory Diseases, 71(5), 335-340.
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Abstract

Background: Community-acquired pneumonia (CAP) is an important cause of morbidity and mortality throughout the world in all age groups. Viral causes of CAP are less well characterized than bacterial causes. We analyzed the characteristics of hospitalized patients with CAP who had a viral pathogen detected by multiplex polymerase chain reaction (PCR). Methods: Multiplex real-time PCR was performed for respiratory viruses in samples collected from 520 adults who developed CAP at Chungnam National University Hospital. Clinical, laboratory, and radiological features at presentation as well as other epidemiological data were analyzed. Results: Of 520 patients with CAP, a viral pathogen was detected in 60 (11.5%), and influenza A was the most common. The virus detection rate in patients with CAP was highest in November. Two or more pathogens were detected in 13 (21.7%) patients. Seven patients had severe disease and were administered in the intensive care unit. Most patients (49/60, 81.7%) had comorbidities. However, nine (15%) patients had no comorbidities, and their age was ＜60 years. The ground glass opacity pattern was the most common radiological feature. Seven (11.7%) patients died from CAP. Conclusion: Viral pathogens are commonly detected in patients with CAP, and a respiratory virus may be associated with the severity and outcome of pneumonia. Careful attention should be paid to the viral etiology in adult patients with CAP.

keywords
Viruses, Pneumonia, Polymerase Chain Reaction

Reference

1.

1. Ministry of Health and Welfare. MHW statistics DB. Seoul: Ministry of Health and Welfare; c2011 [cited 2011 Nov 5]. Available from: http://stat.mw.go.kr [homepate on the internet]. Ministry of Health and Welfare Statistics DB; National Health Insurance part; [updated 2010 DEC 9; cited 2011 JAN 10]. Available from: http://stat.mw.go.kr/stat/data/cm_data_list.jsp? menu_code=MN01010202. Accessed May 10, 2011.

2.

2. Song JH, Jung KS, Kang MW, Kim DJ, Pai H, Suh GY, et al. Treatment guidelines for community-acquired pneumonia in Korea: an evidence-based approach to appropriate antimicrobial therapy. Tuberc Respir Dis 2009;67:281-302.

3.

3. Crowe JE Jr. Human metapneumovirus as a major cause of human respiratory tract disease. Pediatr Infect Dis J 2004;23(11 Suppl):S215-21.

4.

4. van der Hoek L, Pyrc K, Berkhout B. Human coronavirus NL63, a new respiratory virus. FEMS Microbiol Rev 2006;30:760-73.

5.

5. Hayden FG. Rhinovirus and the lower respiratory tract. Rev Med Virol 2004;14:17-31.

6.

6. Lassaunière R, Kresfelder T, Venter M. A novel multiplex real-time RT-PCR assay with FRET hybridization probes for the detection and quantitation of 13 respiratory viruses. J Virol Methods 2010;165:254-60.

7.

7. Brittain-Long R, Westin J, Olofsson S, Lindh M, Andersson LM. Prospective evaluation of a novel multiplex real-time PCR assay for detection of fifteen respiratory pathogens-duration of symptoms significantly affects detection rate. J Clin Virol 2010;47:263-7.

8.

8. File TM. Community-acquired pneumonia. Lancet 2003; 362:1991-2001.

9.

9. Jennings LC, Anderson TP, Beynon KA, Chua A, Laing RT, Werno AM, et al. Incidence and characteristics of viral community-acquired pneumonia in adults. Thorax 2008;63:42-8.

10.

10. Johnstone J, Majumdar SR, Fox JD, Marrie TJ. Viral infection in adults hospitalized with community-acquired pneumonia: prevalence, pathogens, and presentation. Chest 2008;134:1141-8.

11.

11. Marcos MA, Esperatti M, Torres A. Viral pneumonia. Curr Opin Infect Dis 2009;22:143-7.

12.

12. Glezen P, Denny FW. Epidemiology of acute lower respiratory disease in children. N Engl J Med 1973;288: 498-505.

13.

13. Falsey AR, Walsh EE. Viral pneumonia in older adults. Clin Infect Dis 2006;42:518-24.

14.

14. Abed Y, Boivin G. Treatment of respiratory virus infections. Antiviral Res 2006;70:1-16.

15.

15. Jefferson T, Demicheli V, Rivetti D, Jones M, Di Pietrantonj C, Rivetti A. Antivirals for influenza in healthy adults: systematic review. Lancet 2006;367:303-13.

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