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Tuberculosis & Respiratory Diseases

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Vol.71 No.5
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Severe Acute Fibrinous and Organizing Pneumonia with Acute Respiratory Distress Syndrome

Tuberculosis & Respiratory Diseases / Tuberculosis & Respiratory Diseases,
2011, v.71 no.5, pp.368-372
Hyo Jae Kang (Seoul National University)
Sun Mi Choi (Seoul National University)
Yun Jeong Jeong (Seoul National University)
Jong Sun Park (Seoul National University College of Medicine)
Sei Won Lee (Seoul National University)
Ho Il Yoon (Seoul National University)
Jae Ho Lee (Seoul National University)
Choon-Tack Lee (Seoul National University)
Young-Jae Cho (Seoul National University)
Hyo, J. K. , Sun, M. C. , Yun, J. J. , Jong, S. P. , Sei, W. L. , Ho, I. Y. , Jae, H. L. , Choon-Tack, L. , & Young-Jae, C. (2011). Severe Acute Fibrinous and Organizing Pneumonia with Acute Respiratory Distress Syndrome. Tuberculosis & Respiratory Diseases, 71(5), 368-372.
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Abstract

Acute fibrinous and organizing pneumonia is a newly recognized pattern of acute lung injury. A 49-year-old female presented with a cough and worsening dyspnea on exertion. She had no history of smoking and no specific past medical history except exposure of home humidifier containing sterilizer. A chest computed tomography scan showed patchy consolidation with fibrosis in the right lower lobe and ill-defined centrilobular ground glass opacity in both lungs. The pathological findings were patchy areas of lung parenchyma with fibrin deposits in the alveolar ducts and alveoli, and fibrin balls with hemosiderin deposition in the alveolar spaces. The histological pattern of our case is differentiated from diffuse alveolar damage by the absence of hyaline membranes, and from eosinophilic pneumonia by the lack of eosinophils. In our case, the patient was treated with corticosteroid pulse therapy. However, the clinical course became aggravated and she died within two weeks.

keywords
Acute Respiratory Distress Syndrome, Organizing Pneumonia, Cryptogenic, Inhalation Exposure

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