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Tuberculosis & Respiratory Diseases

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Vol.72 No.2
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Prevalence and Risk Factors for Mycobacterium tuberculosis Infection among Contacts of Pulmonary Tuberculosis Patients

Tuberculosis & Respiratory Diseases / Tuberculosis & Respiratory Diseases,
2012, v.72 no.2, pp.140-148

(2012). Prevalence and Risk Factors for Mycobacterium tuberculosis Infection among Contacts of Pulmonary Tuberculosis Patients. Tuberculosis & Respiratory Diseases, 72(2), 140-148.
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Abstract

Background: Detection and treatment of tuberculosis (TB) infection with contact investigation is a key component of TB control program. I evaluated the prevalence and risk factors for TB infection among contacts of recently diagnosed pulmonary TB patients in a tertiary hospital in Korea. Methods: 206 contacts of 90 adult pulmonary TB patients underwent tuberculin skin tests (TST) and chest radiography. The TST results were considered positive with an induration of 10 mm or more, suggesting TB infection. A standardized questionnaire was used to assess risk factors associated with TB infection. Results: TST was positive in 97 of 206 contacts of TB patients (47.1%) and positive rate of TST increased with age. The risk of TB infection was significantly associated with close contact with TB patients (sleeping in the same room) (odd ratio [OR], 4.94; 95% confidence interval [CI], 1.43∼17.00). Conclusion: TB infection rate was higher in the elderly, and the risk of TB infection was significantly increased with close contact of TB patients.

keywords
Tuberculosis, Contact Tracing, Tuberculin Test

Reference

1.

1. Marks SM, Taylor Z, Qualls NL, Shrestha-Kuwahara RJ, Wilce MA, Nguyen CH. Outcomes of contact investigations of infectious tuberculosis patients. Am J Respir Crit Care Med 2000;162:2033-8.

2.

2. Jasmer RM, Nahid P, Hopewell PC. Clinical practice. Latent tuberculosis infection. N Engl J Med 2002;347: 1860-6.

3.

3. Noertjojo K, Tam CM, Chan SL, Tan J, Chan-Yeung M. Contact examination for tuberculosis in Hong Kong is useful. Int J Tuberc Lung Dis 2002;6:19-24.

4.

4. Shim TS, Koh WJ, Yim JJ, Lew WJ. Diagnosis and treatment of latent tuberculosis infection in Korea. Tuberc Respir Dis 2004;57:101-8.

5.

5. Joint Committee for the Development of Korean Guideline for Tuberculosis, Korean Centers for Disease Control and Prevention. Korean guidelines for tuberculosis. 1st ed. Seoul: Medrang Inforang Ltd; 2011.

6.

6. Wang L, Turner MO, Elwood RK, Schulzer M, FitzGerald JM. A meta-analysis of the effect of Bacille Calmette Guérin vaccination on tuberculin skin test measurements. Thorax 2002;57:804-9.

7.

7. Diagnostic standards and classification of tuberculosis in adults and children. Am J Respir Crit Care Med 2000;161:1376-95.

8.

8. Morán-Mendoza O, Marion SA, Elwood K, Patrick D, FitzGerald JM. Risk factors for developing tuberculosis: a 12-year follow-up of contacts of tuberculosis cases. Int J Tuberc Lung Dis 2010;14:1112-9.

9.

9. Aissa K, Madhi F, Ronsin N, Delarocque F, Lecuyer A, Decludt B, et al. Evaluation of a model for efficient screening of tuberculosis contact subjects. Am J Respir Crit Care Med 2008;177:1041-7.

10.

10. Chapman JS, Dyerly MD. Social and other factors in intrafamilial transmission of tuberculosis. Am Rev Respir Dis 1964;90:48-60.

11.

11. Liippo KK, Kulmala K, Tala EO. Focusing tuberculosis contact tracing by smear grading of index cases. Am Rev Respir Dis 1993;148:235-6.

12.

12. Bailey WC, Gerald LB, Kimerling ME, Redden D, Brook N, Bruce F, et al. Predictive model to identify positive tuberculosis skin test results during contact investigations. JAMA 2002;287:996-1002.

13.

13. Chailleux E, Laaban JP, Veale D. Prognostic value of nutritional depletion in patients with COPD treated by long-term oxygen therapy: data from the ANTADIR observatory. Chest 2003;123:1460-6.

14.

14. Choi CM, Kang CI, Kim DH, Kim CH, Kim HJ, Lee CH, et al. The role of TST in the diagnosis of latent tuberculosis infection among military personnel in South Korea. Int J Tuberc Lung Dis 2006;10:1342-6.

15.

15. Bae JM, Kim EH, Wang OB. An usefulness of in vitro interferon gamma assay for the diagnosis of latent tuberculosis infection in middle- and high-school students in Jeju-Shi, Korea. Tuberc Respir Dis 2010;68: 155-61.

16.

16. Hernández-Garduño E, Elwood RK. The prevalence and predictors of tuberculin positivity in subjects screened for reasons other than contact investigation. Can Respir J 2008;15:181-7.

17.

17. Efficacy of various durations of isoniazid preventive therapy for tuberculosis: five years of follow-up in the IUAT trial. International Union Against Tuberculosis Committee on Prophylaxis. Bull World Health Organ 1982;60:555-64.

18.

18. Lienhardt C, Fielding K, Sillah J, Tunkara A, Donkor S, Manneh K, et al. Risk factors for tuberculosis infection in sub-Saharan Africa: a contact study in The Gambia. Am J Respir Crit Care Med 2003;168:448-55.

19.

19. Van Zwanenberg D. The influence of the number of bacilli on the development of tuberculous disease in children. Am Rev Respir Dis 1960;82:31-44.

20.

20. Barnes PF, Bloch AB, Davidson PT, Snider DE Jr. Tuberculosis in patients with human immunodeficiency virus infection. N Engl J Med 1991;324:1644-50.

21.

21. Horsburgh CR Jr. Priorities for the treatment of latent tuberculosis infection in the United States. N Engl J Med 2004;350:2060-7.

22.

22. Dooley KE, Chaisson RE. Tuberculosis and diabetes mellitus: convergence of two epidemics. Lancet Infect Dis 2009;9:737-46.

23.

23. Kim SJ, Hong YP, Lew WJ, Yang SC, Lee EG. Incidence of pulmonary tuberculosis among diabetics. Tuber Lung Dis 1995;76:529-33.

24.

24. Hong YP, Kim SJ, Lew WJ, Lee EK, Han YC. The seventh nationwide tuberculosis prevalence survey in Korea, 1995. Int J Tuberc Lung Dis 1998;2:27-36.

25.

25. Andersen P, Munk ME, Pollock JM, Doherty TM. Specific immune-based diagnosis of tuberculosis. Lancet 2000;356:1099-104.

26.

26. Menzies D, Pai M, Comstock G. Meta-analysis: new tests for the diagnosis of latent tuberculosis infection: areas of uncertainty and recommendations for research. Ann Intern Med 2007;146:340-54.

27.

27. Lew WJ, Jung YJ, Song JW, Jang YM, Kim HJ, Oh YM, et al. Combined use of QuantiFERON-TB Gold assay and chest computed tomography in a tuberculosis outbreak. Int J Tuberc Lung Dis 2009;13:633-9.

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