바로가기메뉴

본문 바로가기 주메뉴 바로가기

A Case of Locally Advanced Well-Differentiated Fetal Adenocarcinoma of the Lung Treated with Concurrent Chemoradiation Therapy

Tuberculosis & Respiratory Diseases / Tuberculosis & Respiratory Diseases,
2013, v.74 no.5, pp.226-230

Chanhee Kyung (Yonsei University College of Medicine)
Sang Young Kim, M.D. (Yonsei University College of Medicine)

Jung-Joon Cha (Yonsei University College of Medicine)


Hee-Jin Park (Yonsei University)
Eun Na Cho, M.D. (Yonsei University College of Medicine)
  • Downloaded
  • Viewed

Abstract

Fetal adenocarcinoma is a rare adenocarcinoma subtype of pulmonary blastoma. A 48-year-old male patient is being referred to our hospital due to progressive dyspnea. A chest X-ray showed a lung mass of unknown origin that was obstructing the right main bronchus. After relieving the airway obstruction with stent insertion via bronchoscopy, a diagnosis of fetal adenocarcinoma is being confirmed through thoracoscopic biopsy. Due to the locally advanced state of the lung cancer, it seemed to be inoperable, and concurrent chemo-radiation therapy was being administered with docetaxel. The stent was removed after improvements in the airway obstruction followed by a lung mass shrinkage. Comparing to other contexts which describe fetal adenocarcinoma as lower grade malignancy with low-associated mortality, herein, we describe a case of locally-advanced fetal adenocarcinoma (T4N3M0). This is the first documented case being treated with concurrent chemoradiation therapy. The followed-up image studies represent a partial response and the patient is currently under further observations.

keywords
Adenocarcinoma, Drug Therapy, Radiotherapy

Reference

1.

Kradin RL, Young RH, Dickersin GR, Kirkham SE, Mark EJ. Pulmonary blastoma with argyrophil cells and lacking sarcomatous features (pulmonary endodermal tumor resembling fetal lung). Am J Surg Pathol 1982;6: 165-72.

2.

Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, et al. International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society international multidisciplinary classification of lung adenocarcinoma. J Thorac Oncol 2011;6:244-85.

3.

Kang CU, Cho DG, Jo MS, Cho KD, Moon YK, Park JK. Well-differentiated fetal adenocarcinoma of the lung: 3 cases report. Korean J Thorac Cardiovasc Surg 2009;42:388-91.

4.

Song DS, Chung WS, Kim H, Kim YH, Kang JH, Lee CB, et al. Surgical treatment of well-differentiated fetal adenocarcinoma: a case report. Korean J Thorac Cardiovasc Surg 2001;34:566-8.

5.

Nakatani Y, Kitamura H, Inayama Y, Kamijo S, Nagashima Y, Shimoyama K, et al. Pulmonary adenocarcinomas of the fetal lung type: a clinicopathologic study indicating differences in histology, epidemiology, and natural history of low-grade and high-grade forms. Am J Surg Pathol 1998;22:399-411.

6.

Van Loo S, Boeykens E, Stappaerts I, Rutsaert R. Classic biphasic pulmonary blastoma: a case report and review of the literature. Lung Cancer 2011;73:127-32.

7.

Sato S, Koike T, Yamato Y, Yoshiya K, Honma K, Tsukada H. Resected well-differentiated fetal pulmonary adenocarcinoma and summary of 25 cases reported in Japan. Jpn J Thorac Cardiovasc Surg 2006; 54:539-42.

8.

Koss MN, Hochholzer L, O'Leary T. Pulmonary blastomas. Cancer 1991;67:2368-81.

Tuberculosis & Respiratory Diseases