Atypical adenomatous hyperplasia (AAH) has been considered to be a precursor lesion of bronchioloalveolar carcinoma (BAC) and pulmonary adenocarcinoma. It usually coexists with BAC and/or an adenocarcinoma. Chest computed tomography reveals multiple well-defined nodules with ground-glass opacity. Usually, AAH does not exceed 10 mm in size. AAH with extensive involvement on one side of the lung field or one that is larger than 2 cm has not been previously reported. We herein report a case of a 71-year-old nonsmoking female with lung AAH of larger than 2 cm.
Brambilla E, Travis WD, Colby TV, Corrin B, Shimosato Y. The new World Health Organization classification of lung tumours. Eur Respir J 2001;18:1059-68.
Chapman AD, Kerr KM. The association between atypical adenomatous hyperplasia and primary lung cancer. Br J Cancer 2000;83:632-6.
Kawakami S, Sone S, Takashima S, Li F, Yang ZG, Maruyama Y, et al. Atypical adenomatous hyperplasia of the lung: correlation between high-resolution CT findings and histopathologic features. Eur Radiol 2001; 11:811-4.
Ishikawa H. Pathologic/high-resolution CT correlation of focal lung lesions 5 mm or less in diameter: detection and identification by multidetector-row CT. Nihon Igaku Hoshasen Gakkai Zasshi 2002;62:415-22.
Jung KW, Park S, Kong HJ, Won YJ, Lee JY, Park EC, et al. Cancer statistics in Korea: incidence, mortality, survival, and prevalence in 2008. Cancer Res Treat 2011;43:1-11.
Ishikawa H, Koizumi N, Naito M, Umezu H, Morita T, Nemoto T, et al. High-resolution CT findings of pulmonary atypical adenomatous hyperplasia of 5 mm or less in diameter. Nihon Igaku Hoshasen Gakkai Zasshi 2003;63:311-5.
Park CM, Goo JM, Lee HJ, Lee CH, Kim HC, Chung DH, et al. CT findings of atypical adenomatous hyperplasia in the lung. Korean J Radiol 2006;7:80-6.
Kayser K, Nwoye JO, Kosjerina Z, Goldmann T, Vollmer E, Kaltner H, et al. Atypical adenomatous hyperplasia of lung: its incidence and analysis of clinical, glycohistochemical and structural features including newly defined growth regulators and vascularization. Lung Cancer 2003;42:171-82.
Bae SH, Jung KJ, Bae JY. Multiple atypical adenomatous hyperplasia mimicking lung to lung metastasis: a case report. Korean J Pathol 2005;39:203-6.
Han AR, Kwon OJ, Kwon YS, Shin J, Koh WJ, Cho EY, et al. An atypical adenomatous hyperplasia presenting as a solitary pulmonary nodule with ground glass opacity. Korean J Med 2007;72(Suppl 2):S221-4.
Lee HS, Choi JS, Seo KH, Na JO, Kim YH, Oh MH, et al. A case of congenital cystic adenomatoid malformation of the lng with atypical adenomatous hyperplasia in adult. Tuberc Respir Dis 2009;66:385-9.
Nomori H, Horio H, Naruke T, Suemasu K, Morinaga S, Noguchi M. A case of multiple atypical adenomatous hyperplasia of the lung detected by computed tomography. Jpn J Clin Oncol 2001;31:514-6.
Seki M, Akasaka Y. Multiple lung adenocarcinomas and AAH treated by surgical resection. Lung Cancer 2007; 55:237-40.
Pastorino U, Calabro E, Tamborini E, Marchiano A, Orsenigo M, Fabbri A, et al. Prolonged remission of disseminated atypical adenomatous hyperplasia under gefitinib. J Thorac Oncol 2009;4:266-7.
Kishi K, Homma S, Kurosaki A, Tanaka S, Matsushita H, Nakata K. Multiple atypical adenomatous hyperplasia with synchronous multiple primary bronchioloalveolar carcinomas. Intern Med 2002;41:474-7.