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Normalization of Elevated CA 19-9 Level after Treatment in a Patient with the Nodular Bronchiectatic Form of Mycobacterium abscessus Lung Disease

Tuberculosis & Respiratory Diseases / Tuberculosis & Respiratory Diseases,
2013, v.75 no.1, pp.25-27

Seo Goo Han (Sungkyunkwan University School of Medicine)
Wooyoul Kim (Sungkyunkwan University School of Medicine)

Junwhi Song (Sungkyunkwan University School of Medicine)
(Sungkyunkwan University School of Medicine)

Ji Hyun Lee (Sungkyunkwan University School of Medicine)
Byung Woo Jhun (Sungkyunkwan University School of Medicine)

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Abstract

Carbohydrate antigen 19-9 (CA 19-9) is a widely-used tumor marker in patients with pancreatic cancer. However, some patients with respiratory disease also exhibit elevated serum CA 19-9 levels. We report a case of normalization of elevated serum CA 19-9 levels after treatment of the nodular bronchiectatic form of Mycobacterium abscessus lung disease. A 40-year-old man visited our hospital because of chronic cough and sputum. A computed tomography scan revealed severe bronchiectasis in the right upper and right middle lobes. Nontuberculous mycobacteria were repeatedly isolated and identified as M. abscessus. The serum CA 19-9 level was elevated to 142.35 U/mL (normal range, <37 U/mL). Surgical resection was performed because of failure of sputum conversion after antibiotic treatment. The serum CA 19-9 level returned to the normal range after surgery. This case suggested that serum CA 19-9 levels could be elevated in patients with the nodular bronchiectatic form of M. abscessus lung disease.

keywords
Bronchiectasis, CA 19-9 Antigen, Nontuberculous Mycobacteria

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Tuberculosis & Respiratory Diseases