A Case of Organizing Pneumonia Associated with FOLFIRI Chemotherapy

The combination chemotherapy of irinotecan with 5-fluorouracil and leucovorin (FOLFIRI regimen) was recentlyproven to be beneficial in patients with advanced colorectal cancer. Pulmonary toxicity is very rare in adverse effects ofirinotecan. No case of organizing pneumonia (also known as bronchiolitis obliterans organizing pneumonia) associatedwith FOLFIRI chemotherapy has been reported. We experienced a case of a 62-year-old man who presented persistentdry cough and progressive dyspnea after receiving chemotherapy with FOLFIRI regimen. After surgical lung biopsy, thepatient was diagnosed with FOLFIRI chemotherapy-induced organizing pneumonia which was successfully treated withsteroid therapy.

keywords: Irinotecan, IFL Protocol, Cryptogenic Organizing Pneumonia, Colorectal Neoplasms

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Article Contents

Vol.77 No.6

A Case of Organizing Pneumonia Associated with FOLFIRI Chemotherapy

Abstract

Reference

Tuberculosis & Respiratory Diseases