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Tuberculosis & Respiratory Diseases

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Vol.78 No.3
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Predictors of Relapse in Patients with Organizing Pneumonia

Tuberculosis & Respiratory Diseases / Tuberculosis & Respiratory Diseases,
2015, v.78 no.3, pp.190-195











& (2015). Predictors of Relapse in Patients with Organizing Pneumonia. Tuberculosis & Respiratory Diseases, 78(3), 190-195.
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Abstract

Background: Although organizing pneumonia (OP) responds well to corticosteroid therapy, relapse is common during dose reduction or follow-up. Predictors of relapse in OP patients remain to be established. The aim of the present study was to identify factors related to relapse in OP patients. Methods: This study was retrospectively performed in a tertiary referral center. Of 66 OP patients who were improved with or without treatment, 20 (30%) experienced relapse. The clinical and radiologic parameters in the relapse patient group (n=20) were compared to that in the non-relapse group (n=46). Results: Multivariate analysis demonstrated that percent predicted forced vital capacity (FVC), PaO2/FiO2, and serum protein level were significant predictors of relapse in OP patients (odds ratio [OR], 0.82; 95% confidence interval [CI], 0.70–0.97; p=0.018; OR, 1.02; 95% CI, 1.00–1.04; p=0.042; and OR, 0.06; 95% CI, 0.01–0.87; p=0.039, respectively). Conclusion: This study shows that FVC, PaO2/FiO2 and serum protein level at presentation can significantly predict relapse in OP patients.

keywords
Cryptogenic Organizing Pneumonia, Recurrence, Vital Capacity

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