바로가기메뉴

본문 바로가기 주메뉴 바로가기

Tuberculosis & Respiratory Diseases

Article Contents

Prev Next
e-Submission

Vol.78 No.4
Citation Share

Endobronchial ALK-Positive Anaplastic Large Cell Lymphoma Presenting Massive Hemoptysis

Tuberculosis & Respiratory Diseases / Tuberculosis & Respiratory Diseases,
2015, v.78 no.4, pp.390-395











& (2015). Endobronchial ALK-Positive Anaplastic Large Cell Lymphoma Presenting Massive Hemoptysis. Tuberculosis & Respiratory Diseases, 78(4), 390-395.
  • Downloaded
  • Viewed
PDF Download

Abstract

Primary anaplastic large cell lymphoma (ALCL) of the lung is highly aggressive and quite rare. We report here a case of anaplastic lymphoma kinase–positive endobronchial ALCL, that was initially thought to be primary lung cancer. A 68-year-old woman presented with hemoptysis, dyspnea, and upper respiratory symptoms persisting since 1 month. The hemoptysis and and bronchial obstruction lead to respiratory failure, prompting emergency radiotherapy and steroid treatment based on the probable diagnosis of lung cancer, although a biopsy did not confirm malignancy. Following treatment, her symptoms resolved completely. Chest computed tomography scan performed 8 months later showed increased and enlarged intra-abdominal lymph nodes, suggesting lymphoma. At that time, a lymph node biopsy was recommended, but the patient refused and was lost to follow up. Sixteen months later, the patient revisited the emergency department, complaining of persistent abdominal pain since several months. A laparoscopic intra-abdominal lymph node biopsy confirmed a diagnosis of ALCL.

keywords
Large Cell Lymphoma, Respiratory Failure, Hemoptysis

Reference

1.

1. Me deiros LJ., Elenitoba-Johnson KS. (2007), Anaplastic large cell lymphoma. Am J Clin Pathol, 127,707-22.

2.

2. Ki m JH., Lee SH., Park J., Kim HY., Lee SI., Park JO. (2004), Primary pulmonary non-Hodgkin’s lymphoma. Jpn J Clin Oncol, 34,510-4.

3.

3. Ru sh WL., Andriko JA., Taubenberger JK., Nelson AM., Abbondanzo SL., Travis WD. (2000), Primary anaplastic large cell lymphoma of the lung: a clinicopathologic study of five patients. Mod Pathol, 13,1285-92.

4.

4. Ba rthwal MS., Deoskar RB., Falleiro JJ., Singh P. (2005), Endobronchial non-Hodgkin’s lymphoma. Indian J Chest Dis Allied Sci, 47,117-20.

5.

5. Xu X. (2014), ALK-negative anaplastic large cell lymphoma primarily involving the bronchus: a case report and literature review. Int J Clin Exp Pathol, 7,460-3.

6.

6. Ha n SH., Maeng YH., Kim YS., Jo JM., Kwon JM., Kim WK. (2014), Primary anaplastic large cell lymphoma of the lung presenting with acute atelectasis. Thorac Cancer, 5,78-81.

7.

7. Fe rraro P., Trastek VF., Adlakha H., Deschamps C., Allen MS., Pairolero PC. (2000), Primary non-Hodgkin’s lymphoma of the lung. Ann Thorac Surg, 69,993-7.

8.

8. Ya ng HB., Li J., Shen T. (2007), Primary anaplastic large cell lymphoma of the lung. Report of two cases and literature review. Acta Haematol, 118,188-91.

9.

9. Le e SA., Kim DH., Jeon GS. (2012), Covered bronchial stent insertion to manage airway obstruction with hemoptysis caused by lung cancer. Korean J Radiol, 13,515-20.

Tuberculosis & Respiratory Diseases

e-Submission OA Policy