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Tuberculosis & Respiratory Diseases

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Vol.79 No.3
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Association of Serum Vitamin D Levels with Bacterial Load in Pulmonary Tuberculosis Patients

Tuberculosis & Respiratory Diseases / Tuberculosis & Respiratory Diseases,
2016, v.79 no.3, pp.153-157
B. Yuvaraj (Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER))
M. G. Sridhar (Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER))
S. Vinod Kumar (Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER))
T. Kadhiravan (Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER))
B., Y. , M., G. S. , S., V. K. , & T., K. (2016). Association of Serum Vitamin D Levels with Bacterial Load in Pulmonary Tuberculosis Patients. Tuberculosis & Respiratory Diseases, 79(3), 153-157.
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Abstract

Background: Vitamin D is known to have diverse effects on various systems in the body. There is evidence to suggest that a link exists between the serum vitamin D status and tuberculosis. The present study was designed to assess the alterations in serum 25-hydroxyvitamin D levels in newly diagnosed sputum acid fast bacilli (AFB) positive pulmonary tuberculosis patients and to study the association, if any, between serum vitamin D levels and different levels of sputum smear positivity. Methods: Serum 25-hydroxyvitamin D levels were estimated in 65 sputum AFB positive pulmonary tuberculosis patients and 65 age and gender-matched healthy controls. Results: The levels of serum 25 hydroxy-vitamin D in tuberculosis patients were not statistically different from the levels of serum 25 hydroxy-vitamin D in healthy controls. However, among patients with pulmonary tuberculosis, there was a significant negative correlation between the levels of serum 25 hydroxy-vitamin D and levels of sputum positivity. Conclusion: Serum vitamin D levels negatively correlates with bacterial load in patients with active pulmonary tuberculosis.

keywords
Vitamin D, Tuberculosis, Pulmonary

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