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Tuberculosis & Respiratory Diseases

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Vol.83 No.1
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Clinical Characteristics of Chronic Cough in Korea

Tuberculosis & Respiratory Diseases / Tuberculosis & Respiratory Diseases,
2020, v.83 no.1, pp.31-41
https://doi.org/10.4046/trd.2019.0018

Jin Woo Kim (The Catholic University of Korea)
Eun Young Choi (Yeungnam University)
Seung Hun Jang (Hallym University)

Hye Seon Kang (The Catholic University of Korea)

Jong Min Lee (The Catholic University of Korea)
Sung-Kyung Kim (The Catholic University of Korea)
Jong-Wook Shin (Chung-Ang University)
So Young Park (Chungnam University)
Chin Kook Rhee (The Catholic University of Korea)
Ji-Yong Moon (Hanyang University)
Yee Hyung Kim (Kyung Hee University)
Hyun Lee (Hanyang University)
Yong Hyun Kim (The Catholic University of Korea)
Je Hyeong Kim (Korea University)
Sang Haak Lee (The Catholic University of Korea)
Deog Kyeom Kim (Seoul National University)
Kwang Ha Yoo (Konkuk University)
Dong Gyu Kim (Hallym University)

Hui Jung Kim (Wonkwang University)
Hyoung Kyu Yoon (The Catholic University of Korea)
Cough Study Group of the Korean Academy of Tuberculosis and Respiratory Diseases (Cough Study Group of the Korean Academy of Tuberculosis and Respiratory Diseases)
Jin, W. K. , Eun, Y. C. , Seung, H. J. , Hye, S. K. , Jong, M. L. , Sung-Kyung, K. , Jong-Wook, S. , So, Y. P. , Chin, K. R. , Ji-Yong, M. , Yee, H. K. , Hyun, L. , Yong, H. K. , Je, H. K. , Sang, H. L. , Deog, K. K. , ... Cough, S. G. o. t. K. A. o. T. a. R. D. (2020). Clinical Characteristics of Chronic Cough in Korea. Tuberculosis & Respiratory Diseases, 83(1), 31-41, https://doi.org/10.4046/trd.2019.0018
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Abstract

Background: Chronic cough is defined as a cough lasting more than 8 weeks and socio-economic burden of chronic cough is enormous. The characteristics of chronic cough in Korea are not well understood. The Korean Academy of Tuberculosis and Respiratory Diseases (KATRD) published guidelines on cough management in 2014. The current study evaluated the clinical characteristics of chronic cough in Korea and the efficacy of the KATRD guidelines. Methods: This was a multi-center, retrospective observational study conducted in Korea. The participants were over 18 years of age. They had coughs lasting more than 8 weeks. Subjects with current pulmonary diseases, smokers, ex-smokers with more than 10 pack-years or who quit within the past 1 year, pregnant women, and users of cough-inducing medications were excluded. Evaluation and management of cough followed the KATRD cough-management guidelines. Results: Participants with chronic cough in Korea showed age in the late forties and cough duration of more than 1 year. Upper airway cough syndrome was the most common cause of cough, followed by cough-variant asthma (CVA). Gastro-esophageal reflux diseases and eosinophilic bronchitis were less frequently observed. Following the KATRD cough-management guidelines, 91.2% of the subjects improved after 4 weeks of treatment. Responders were younger, had a longer duration of cough, and an initial impression of CVA. In univariate and multivariate analyses, an initial impression of CVA was the only factor related to better treatment response. Conclusion: The causes of chronic cough in Korea differed from those reported in other countries. The current Korean guidelines proved efficient for treating Korean patients with chronic cough.

keywords
Cough, Cohort Studies, Epidemiology, Guideline, Diagnosis, Disease Management

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