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Tuberculosis & Respiratory Diseases

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Vol.85 No.1
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The Long-term Efficacy of Domiciliary Noninvasive Positive-Pressure Ventilation in Chronic Obstructive Pulmonary Disease: A Meta-Analysis of Randomized Controlled Trials

Tuberculosis & Respiratory Diseases / Tuberculosis & Respiratory Diseases,
2022, v.85 no.1, pp.47-55
https://doi.org/10.4046/trd.2021.0062
Yun Su Sim, M.D. (Hallym University Kangnam Sacred Heart Hospital)
So Young Park, M.D., Ph.D. (Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul)
Kwang Ha Yoo, M.D. Ph.D. (Konkuk University School of Medicine)
Yong Bum Park, M.D., Ph.D. (Department of Internal Medicine, Hallym University Kandong Sacred Heart Hospital)
Chin Kook Rhee, M.D., Ph.D. (The Catholic University of Korea)
Jinkyeong Park, M.D., Ph.D. (Division of Pulmonary and Critical Care Medicine, Samsung Medical Center, Sungkyunkwan University Sc)
Hye Yun Park, M.D., Ph.D. (Department of Medicine, Samsung Medical Center)
Yong Il Hwang, M.D., Ph.D. (Department of Medicine, Hallym University Sacred Heart Hospital)
Dong Ah Park, Ph.D. (Division of Healthcare Technology Assessment Research, Office of Health Technology Assessment Resear)
Yun, S. S. M. , So, Y. P. M. P. , Kwang, H. Y. M. P. , Yong, B. P. M. P. , Chin, K. R. M. P. , Jinkyeong, P. M. P. , Hye, Y. P. M. P. , Yong, I. H. M. P. , & Dong, A. P. P. (2022). The Long-term Efficacy of Domiciliary Noninvasive Positive-Pressure Ventilation in Chronic Obstructive Pulmonary Disease: A Meta-Analysis of Randomized Controlled Trials. Tuberculosis & Respiratory Diseases, 85(1), 47-55, https://doi.org/10.4046/trd.2021.0062
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Abstract

Background: We evaluated the long-term effects of domiciliary noninvasive positive-pressure ventilation (NIPPV) usedto treat patients with chronic obstructive pulmonary disease (COPD). Methods: Databases were searched to identify randomized controlled trials of COPD with NIPPV for longer than 1 year. Mortality rates were the primary outcome in this meta-analysis. The eight trials included in this study comprised datafrom 913 patients. Results: The mortality rates for the NIPPV and control groups were 29% (118/414) and 36% (151/419), suggesting astatistically significant difference (risk ratio [RR], 0.79; 95% confidence interval [CI], 0.65–0.95). Mortality rates werereduced with NIPPV in four trials that included stable COPD patients. There was no difference in admission, acuteexacerbation and quality of life between the NIPPV and control groups. There was no significant difference in withdrawalrates between the two groups (RR, 0.99; 95% CI, 0.72–1.36; p=0.94). Conclusion: Maintaining long-term nocturnal NIPPV for more than 1 year, especially in patients with stable COPD,decreased the mortality rate, without increasing the withdrawal rate compared with long-term oxygen treatment.

keywords
Noninvasive Positive-Pressure Ventilation, Chronic Obstructive Pulmonary Disease, Mortality

Tuberculosis & Respiratory Diseases

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