Immune Evasion of G-CSF and GM-CSF in Lung Cancer
Tuberculosis & Respiratory Diseases / Tuberculosis & Respiratory Diseases,
2024, v.87 no.1, pp.22-30
https://doi.org/10.4046/trd.2023.0037
Chae Uk Chung, M.D., Ph.D. (Chungnam National University Hospital)
Yeonhee Park, M.D., Ph.D. (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Daejeon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Daejeon,)
Chae,
U.
C.
M.
P.
, &
Yeonhee,
P.
M.
P.
(2024). Immune Evasion of G-CSF and GM-CSF in Lung Cancer. Tuberculosis & Respiratory Diseases, 87(1), 22-30, https://doi.org/10.4046/trd.2023.0037
Abstract
Tumor immune evasion is a complex process that involves various mechanisms, suchas antigen recognition restriction, immune system suppression, and T cell exhaustion.
The tumor microenvironment contains various immune cells involved in immune evasion.
Recent studies have demonstrated that granulocyte colony-stimulating factor(G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) induce immuneevasion in lung cancer by modulating neutrophils and myeloid-derived suppressorcells. Here we describe the origin and function of G-CSF and GM-CSF, particularlytheir role in immune evasion in lung cancer. In addition, their effects on programmeddeath-ligand 1 expression and clinical implications are discussed.
- keywords
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Granulocyte Colony-Stimulating Factor,
Granulocyte-Macrophage Colony- Stimulating Factor,
Neutrophils,
Myeloid-Derived Suppressor Cell,
Programmed Death-Ligand 1,
Immune Evasion