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open access
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ISSN : 0376-4672
Purpose : The purpose of this study was to evaluate the clinical effect of Vitamin C, Vitamin E, lysozyme, carbazochrome complex medicine(IGATAN®) for periodontal disease Material and Methods : The study was performed by double blinded, ramdomized method. Forty two subjects diagnosed as chronic incipient or moderate periodontitis at department of periodontology, Yonsei Dental Hospital were included in the study. This study was approved by Institutional Review Board , Yonsei Universtiy Hospital. All subjects received scaling at their first examination and second examination was scheduled after 2 weeks. At second examination, periodontal parameters such as plaque index(PI), gingival index(GI), probing depth(PD), bleeding on probing(BOP), gingival recession(GR) and clinical attachment level(CAL) were recorded(Baseline) with prescription of Vitamin C, Vitamin E, lysozyme, carbazochrome complex(IGATAN®) (Experimental group 23 subjects) or placebo medicine(Control group; 19 subjects). The subjects were recalled after 4 weeks for periodontal parameters measurement. Results : In the experimental groups, PI, GI, CAL and BOP scores were significantly reduced at 4 weeks compared to baseline. A statistically significant decrease in GI and BOP scores were observed in the experimental group compared to the control group. Conclusion : It can be concluded that Vitamin C, Vitamin E, lysozyme, carbazochrome complex medicine(IGATAN®) have an effect in reducing gingival bleeding and improving periodontal inflammatory condition inchronic incipient- moderate periodontitis.
1. Kornman KS, Loe H. The role of local factors in the etiology of periodontal diseases. Periodontol 2000 1993;2:83-97.
2. Sbordone L, Bortolaia C. Oral microbial biofilms and plaquerelated diseases: microbial communities and their role in the shift from oral health to disease. Clin Oral Investig 2003;7:181-188.
3. Page RC, Kornman KS. The pathogenesis of human periodontitis: an introduction. Periodontol 2000 1997;14:9-11.
4. Battino M, Bullon P, Wilson M, Newman H. Oxidative injury and inflammatory periodontal diseases: the challenge of anti-oxidants to free radicals and reactive oxygen species. Crit Rev Oral Biol Med 1999;10:458-476.
5. Page RC. Milestones in periodontal research and the remaining critical issues. J Periodontal Res 1999;34:331-339.
6. Slots J. Selection of antimicrobial agents in periodontal therapy. J Periodontal Res 2002;37:389-398.
7. Reddy MS, Geurs NC, Gunsolley JC. Periodontal host modulation with antiproteinase, anti-inflammatory, and bone-sparing agents. A systematic review. Ann Periodontol 2003;8:12-37.
8. Braatz L, Garrett S, Claffey N, Egelberg J. Antimicrobial irrigation of deep pockets to supplement non-surgical periodontal therapy. II. Daily irrigation. J Clin Periodontol 1985;12:630-638.
9. Hazen SP. The role of nutrition in periodontal disease. Ala J Med Sci 1968;5:328-335.
10. Nishida M, Grossi SG, Dunford RG et al. Dietary vitamin C and the risk for periodontal disease. J Periodontol 2000;71:1215-1223.
11. Melnick SL, Alvarez JO, Navia JM, Cogen RB, Roseman JM. A case-control study of plasma ascorbate and acute necrotizing ulcerative gingivitis. J Dent Res 1988;67:855-860.
12. Pussinen PJ, Laatikainen T, Alfthan G, Asikainen S, Jousilahti P. Periodontitis is associated with a low concentration of vitamin C in plasma. Clin Diagn Lab Immunol 2003;10:897-902.
13. Ito T, Komiya-Ito A, Arataki T et al. Relationship between antimicrobial protein levels in whole saliva and periodontitis. J Periodontol 2008;79:316-322.
14. Cohen ME, Meyer DM. Effect of dietary vitamin E supplementation and rotational stress on alveolar bone loss in rice rats. Arch Oral Biol 1993;38:601-606.
15. Moriuchi H, Kashiwada Y, Arai I, Yuizono T. Effects of carbazochrome sodium sulfonate (AC-17) on oleic acid-induced lung injury. Pharmacol Toxicol 1995;77:238-240.
16. Geesin JC, Darr D, Kaufman R, Murad S, Pinnell SR. Ascorbic acid specifically increases type I and type III procollagen messenger RNA levels in human skin fibroblast. J Invest Dermatol 1988;90:420-424.
17. Suomalainen K, Sorsa T, Lindy O et al. Hypochlorous acid induced activation of human neutrophil and gingival crevicular fluid collagenase can be inhibited by ascorbate. Scand J Dent Res 1991;99:397-405.
18. Minn WK, Lee M. Effects of Ascorbic acid and unsaponifiable fractions of ZEA MAYS L. on the experimentally induced periodontitis in rats. J Korean Acad Periodontol 1988;18:6-18.
19. Asman B. Peripheral PMN cells in juvenile periodontitis. Increased release of elastase and of oxygen radicals after stimulation with opsonized bacteria. J Clin Periodontol 1988;15:360-364.
20. Halliwell B, Gutteridge JM. Oxygen toxicity, oxygen radicals, transition metals and disease. Biochem J 1984;219:1-14.
21. Surna A, Kubilius R, Sakalauskiene J et al. Lysozyme and microbiota in relation to gingivitis and periodontitis. Med Sci Monit 2009;15:CR66-73.
22. Saeki Y, Ito Y, Shibata M et al. Antimicrobial action of natural substances on oral bacteria. Bull Tokyo Dent Coll 1989;30:129-135.
23. Younes R, Yousfi M, Ghorra C et al. The defensive role of lysozyme in human gingiva in inflammatory periodontal disease. J Periodontal Res 2008.
24. Badersten A, Nilveus R, Egelberg J. Effect of nonsurgical periodontal therapy. I. Moderately advanced periodontitis. J Clin Periodontol 1981;8:57-72.
25. Stoeken JE, Paraskevas S, van der Weijden GA. The long-term effect of a mouthrinse containing essential oils on dental plaque and gingivitis: a systematic review. J Periodontol 2007;78:1218-1228.
26. Loe H. The Gingival Index, the Plaque Index and the Retention Index Systems. J Periodontol 1967;38:Suppl:610-616.
27. Greenstein G, Caton J, Polson AM. Histologic characteristics associated with bleeding after probing and visual signs of inflammation. J Periodontol 1981;52:420-425.
28. Armitage GC, Dickinson WR, Jenderseck RS, Levine SM, Chambers DW. Relationship between the percentage of subgingival spirochetes and the severity of periodontal disease. J Periodontol 1982;53:550-556.
29. Meitner SW, Zander HA, Iker HP, Polson AM. Identification of inflamed gingival surfaces. J Clin Periodontol 1979;6:93-97.
30. Greenstein G. The role of bleeding upon probing in the diagnosis of periodontal disease. A literature review. J Periodontol 1984;55:684-688.
31. Leggott PJ, Robertson PB, Rothman DL, Murray PA, Jacob RA. The effect of controlled ascorbic acid depletion and supplementation on periodontal health. J Periodontol 1986;57:480-485.
32. IWAMOTO HKM. Clinical evaluation of lysozyme capsule containing Vitamin C,E and K1 in periodontal disease. Journal of the japanese society of periodontology 1993;35 134.