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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

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스트레스와 에탄올로 유발된 mouse의 위점막 손상에 대한 귀비탕의 예방효과

The Defensive Effect of Keuibi-tang on the Gastric Mucous Membrane of Mouse Injured by Stress and Ethanol

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2003, v.24 no.1, pp.155-168
김학재 (동국대학교)
최준혁 (동국대학교)
임성우 (동국대학교)
김학재, 최준혁, & 임성우. (2003). 스트레스와 에탄올로 유발된 mouse의 위점막 손상에 대한 귀비탕의 예방효과. 대한한의학회지, 24(1), 155-168.
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Abstract

This study was carried out to investigate the effect of Keuibi-tang(KBT) on the injury of gastric mucous membrane by stress and ethanol in mice.The normal group is that no inflammation elicited mice. Two control groups are that gastro-inflamation elicitated mice by stress and ethanol. Two sample groups are that KBT administered mice before gastro-inflammation elicitation.In the common morphology and histochemical change, two control groups were observed various injury such as hemorrhagic erosion and ulcer, while sample group was as same as normal group. In the immunohistochemical change, the distributions of PNA and COX-1 treated with KBT noticeably increased than control group(p<0.05). The distributions of NF-κB p50, COX-2 and TUNEL treated with KBT noticeably decreased than control group(P<0.05). And the distribution of KBT was as same as normal group.According to the above results, it is supposed that KBT is applicable to gastritis and gastric ulcer by stress and alcoholic drinks.

keywords
Keuibi-tang, the injury of gastric mucous membrane, COX-1, NF-κB p50, COX-2, Keuibi-tang, the injury of gastric mucous membrane, COX-1, NF-κB p50, COX-2


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