- P-ISSN 1010-0695
- E-ISSN 2288-3339
- Apply for Authority
- P-ISSN1010-0695
- E-ISSN2288-3339
Article Detail
Home > Article Detail
Effect of Galhwahyejung-tang (GHT) on Alcohol-induced Oxidative Stress in Rats
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2010, v.31 no.6, pp.1-7
(Dongeui University)
(Dongeui University)
(Daejeon University)
(Dongeui University)
(Daejeon University)
Dong-Gyu,
K.
, Tae-Hwan,
K.
, Hyung-Geug,
K.
, &
(2010). Effect of Galhwahyejung-tang (GHT) on Alcohol-induced Oxidative Stress in Rats. Journal of Korean Medicine, 31(6), 1-7.
- Downloaded
- Viewed
Abstract
Objectives: This study was aimed to investigate the effects of Galhwahyejung-tang (GHT) on alcohol-induced oxidative stress in rat model. Methods: Twenty SD rats were orally administrated with 40% ethanol (mL/kg) combined with GHT (50, 100, 200mg/kg) or distilled water for 2 weeks. Biochemistry in blood, malondialdehyde (MDA), total reactive oxygen species (ROS), and total antioxidant capacity (TAC) in serum, liver, brain, and kidney were determined. Results: GHT treatment significantly ameliorated the alcohol-induced alteration of hepatic enzyme; especially AST and ALT. GHT treatment also ameliorated the increase of MDA in liver, ROS level in serum and brain. GHT treatment reduced the depletion of antioxidant capacity in serum and brain. Conclusion: These results that GHT has antioxidant properties explaining the relevance of clinical application and its partial mechanisms of GHT.
- keywords
- Alcohol, oxidative stress, Galhwahyejung-tang, traditional Korean medicine
Reference
1
1 Graham K, Massak A, Demers A, Rehm J. Does the association between alcohol consumption and depression depend on how they are measured? Alcohol Clin Exp Res. 2007; 31:78-88.
2
2 Bok CH. Alcoholic Liver Disease. Korean J. of Gastroenterology. 2009; 53:275-82.
3
3 Chung WJ, Lee SM, Han KH. Socio-economic costs of alcohol by beverage type. Korean Public Health Research. 2006 32:1-8.
4
4 Meier P, Seitz HK. Age, alcohol metabolism and liver disease. Curr Opin Clin Nutr Metab Care. 2008; 11(1):21-6.
5
5 Lieber CS. Pathogenesis and treatment of alcoholic liver disease: progress over the last 50 years. Rocz Akad Med Bialymst. 2005; 50:7-20.
6
6 Hoek JB, Pastorino JG. Ethanol, oxidative stress, and cytokine-induced liver cell injury. Alcohol. 2002; 27(1):63-8.
7
7 Hong SW, Kim JH, Whang WW. [Observation of literature on observative why to damage to drinking]. J. Korean Oriental Med. 1990 11:9-23.
8
8 Son CG, Choi BL, Shin JW, Choi WJ. Effects of Gamichunggantang (GCT) on alcohol metabolism and alcoholic liver disease. J. Korean Oriental Med. 2001; 2(1): 89-98.
9
9 Mao ZG, Li SX, Jiang MZ. Clinical observation on alcoholic fatty liver treated by GeHuaJieCheng decoction. J. Emergency TCM. 2005; 14:838-40.
10
10 Weng WD. Effects of traditional Chinese medicine GehuaJiechen decoction on fatty liver induced by alcohol in rats. Chinese J. Integrative Trad West Med Dig. 2008 16:162-4.
11
11 Ahn TK, Shin JW, Cho JK, Cho JH, Yoo HS, Lee YW, et al. Effects of Galhwahyejung-tang on Protection from Alcohol-induced Liver Injury. J. Korean Oriental Med. 2005 26:76-84.
12
12 Institute of Laboratory Animal Resources, Commision on Life sciences, National Resaerch Council. 1996. Guide for the Care and Use of Laboratory Animals. National Academy Press: Washington, DC.
13
13 Mihara M, Uchiyama M. Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal Biochem 1978; 186(1):271-8.
14
14 Hayashi I, Morishita Y, Imai K, Nakamura M, Nakachi K, Hayashi T. High-throughput spectrophotometric assay of reactive oxygen species in serum. Genetic toxicology and environmental mutagenesis. 2007; 631:55-61.
15
15 Kambsyashi Y, Binh NT, Asakura HW, Hibino Y, Hitomi Y, Nakamura H, et al. Efficient assay for total antioxidant capacity in human plasma using a 96-Well micro plate. J. Clin. Biochem. Nutr. 2009; 44:46-51.
16
16 A Sigh. Free Radicals and Antioxidants in Biomedicine: CRC Handbook.1st ed. Boca Raton, FL: CRC Press. 1989:17-28.
17
17 Albano E. Alcohol, oxidative stress and free radical damage. Proceedings of the Nutrition Society 2006; 65:278-90.
18
18 Chae JG, Shin HM, Kim GW. Galwhahaejungtang inhibits ethanol-induced gastric injury in rats. J. Korean Oriental Med. 1999; 20(1):113-21.
19
19 Wang DP, Tan XL. The protective effects of GehuaJiechen decoction on alcoholic liver diseases. J. Guiyang Chinese TCM, 2002; 24(2):55-6.
20
20 Castro GD, Delgado de Layno AM, Castro JA. Liver nuclear ethanol metabolizing systems (NEMS) producing acetaldehyde and 1-hydroxyethyl free radicals. Toxicology. 1998; 129(2-3):137-44.
21
21 Heo Jun. Dongeuibogam, Seoul, Faren publisher, 2005. p2103.
- Downloaded
- Viewed
- 0KCI Citations
- 0WOS Citations
Other articles from this issue
- Effect of Galhwahyejung-tang (GHT) on Alcohol-induced Oxidative Stress in Rats
- Simultaneous Determination of Albiflorin, Cinnamaldehyde, Cinnamic Acid, Daidzin, Glycyrrhizin, Liquiritin, Paeoniflorin and Puerarin in Galgeun-tang by HPLC-PDA
- Study of Characteristics of Patients with Chronic Fatigue
- Acupuncture and Cortisol Levels: a Systematic Review
- Donguibogam or DongUiBoGam: Is It Still a Different Book? - A Study on the Translation of Donguibogam into English Orthography -
- Therapeutic Potential of Atopy-camp: A pilot study
- Ethanol Extract of Cynanchum wilfordii Produces Endothelium-Dependent Relaxation in Rat Aorta and Anti-inflammatory Activity in Human Aortic Smooth Muscle Cells
- A Case Report of Chemotherapy-induced Neuropathic Pain Treated with Oriental Medicine
- more
Recommanded Articles
This website recommended the use the Chrome browser for journal website.