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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

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淸血地黃湯이 Phenylhydrazine으로 유발한 용혈성 빈혈 흰쥐에 미치는 영향

Effects of Chunghyuljihwang-tang on Phenylhydrazine-induced Hemolytic Anemia in Rats

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2011, v.32 no.1, pp.130-140
양형주 (경희대학교)
우홍정 (경희대학교)
양형주, & 우홍정. (2011). 淸血地黃湯이 Phenylhydrazine으로 유발한 용혈성 빈혈 흰쥐에 미치는 영향. 대한한의학회지, 32(1), 130-140.
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Abstract

Objectives: This study was performed in order to investigate the anti-hemolytic effect of Chunghyuljihwang-tang (CHJHT, Qingxuedihuang-tang) on phenylhydrazine-induced hemolytic anemia in Rats. Materials and Methods: Hemolytic anemia model of rats were induced by phenylhydrazine(PHZ, 40mg/kg/day, i.p.)for 3days. Male Sprague-Dawley rats were divided into three groups for their treatment. Normal group was injected normal saline for 3 days with distilled water(d.w.) orally, control group was injected PHZ for 3 days with d.w. and CHJHT group was injected PHZ for 3 days with administration of CHJHT for 10 days. RBC(Red blood cell), Hb (hemoglobin), mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration,reticulocyte were determined on day 0, 4, 7, 10. Body weight was investigated on day 0, 2, 4, 6, 8, 10 and the weight of spleen was measured on day 10. Results: For CHJHT group, the levels of RBC and Hb were significantly higher than control group on day 4, and the concentration of hemoglobin on day 7 was increased more than control group. Moreover, reticulocyte was significantly decreased on day 10 more than control group. These results could be concluded that CHJHT suppressed the hemolytic anemia by PHZ and improved hematological values of anemia earlier.

keywords
Chunghyuljihwang-tang, hemolytic anemia, phenylhydrazine


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