- P-ISSN 1010-0695
- E-ISSN 2288-3339
- Apply for Authority
- P-ISSN1010-0695
- E-ISSN2288-3339
Article Detail
Home > Article Detail
Effects of Concurrent Administration of Hyeolbuchukeo-tang and Aspirin on Atherosclerosis in the ApoE^((-/-)) Mouse
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2011, v.32 no.1, pp.164-174
&
(2011). Effects of Concurrent Administration of Hyeolbuchukeo-tang and Aspirin on Atherosclerosis in the ApoE^((-/-)) Mouse. Journal of Korean Medicine, 32(1), 164-174.
- Downloaded
- Viewed
Abstract
Objective: The antiplatelet agent aspirin has been widely used for treating atherosclerosis in western medicine, and its efficacy has been proven in cardiac and extracardiac vascular diseases. On the other hand, Hyeolbuchukeo-tang has been widely used for treating blood stasis syndrome in traditional medicine. Therefore we investigated whether Hyeolbuchukeo-tang could have a synergic effect along with aspirin. Methods & Materials: Male ApoE^((-/-)) mice were randomly divided into three different experimental groups: a non-treated group(Control group), an aspirin-treated group(AP group), and an aspirin with Hyeolbuchukeo-tang-treated group(APH group). The control group was fed only an atherogenic diet, the AP group an atherogenic diet plus Aspirin 5 ㎎/㎏,and the APH group an atherogenic diet plus Aspirin 5 ㎎/㎏ with Hyeolbuchukeo-tang 100 ㎎/㎏. We investigated plasma lipid with liver function test, and performed the histological investigation of liver and abdominal aorta. Results:1. We investigated photomicrographic changes of liver and abdominal aorta tissue. They showed that histological injury of aorta and lipid accumulations of the liver were lower in the AP and APH groups than in the control group. 2. In the APH group, plasma triglyceride levels were significantly lower than those in the control and AP groups. 3. There were no differences in aspartate aminotransferase and alanine aminotransferase levels among the control, AP and APH groups. Conclusion: The above results show that a combined treatment of Hyeolbuchukeo-tang and aspirin has a somewhat synergic effect in terms of inhibiting vessel injury and decreasing lipid deposits on liver cells without liver toxicity.
- keywords
- Aspirin, atherosclerosis, hypertriglyceridemia, Hyeolbuchukeo-tang(血府逐瘀湯), ApoE^((-/-)) mouse
Reference
1
1. 통계청. 2007년 사망원인 통계연보. 서울. 2008.
2
2. 천병렬. 한국인의 고지혈증 및 동맥경화증 질환의 시대적 변천. 한국지질동맥경화학회지. 2001;11(1): 29-38
3
3. 채인호. 고지혈증 있는 환자에서 뇌졸중 및 관상 동맥질환의 일차예방. 한국지질동맥경화학회지. 2001;11(3):362-365
4
4. Choi SH, Ahn KS, Moon JJ, Park JA. A Study on the Effect of Samchilgeun on Thrombosis and elevated Blood Viscosity. J of Oriental Medical Pathology. 1992;7(1):163-170
5
5. 上海中醫學院. 方劑學. 香港:商務印書館 1977:177
6
6. Baek KH, Kum KC, Lee YT. The effect of Hyulbuchuckohtang on hyperlipidemia rats. J of Oriental Physiology. 1998;13(1):102-109
7
7. 添興德. 血府逐瘀湯對氣滯血瘀型高脂血證降脂作 用的臨床觀察與實驗硏究. 中西醫結合雜誌. 1988; 8(10):601-603
8
8. Choi SJ. Effect of Hyeolbuchugeo-tang on hyperlipidemia in streptozotocin-induced diabetic rats. Dept of Oriental Medicine, Graduate School of Kyungwon University, 2005.
9
9. Pi CM, Chong MS, Kim HJ, Cho HY, Choi YH, Lee KN. Effects of Hyolbuchukeo-tang extracts on blood and liver of hyperlipidemia rats induced by high fat diet. Kor J Oriental Preventive Medical Society. 2009;13(1):41-58
10
10. Choi SH. Effects of Hyeolbusueotang on thrombosis and ecchymoma. J Korean Oriental Medicine. 1984;8(2):84-85
11
11. Min BK, Kim SJ, Kang JH, Park JW, Yun IJ, Oh MS. Clinical Investigation about Deep Vein Thrombosis after cystostomy; case report. The Journal of the Korea Institute of Oriental Medical Informatics. 2005;11(2):14-22
12
12. Kang JS, Park SH, Song MK, An YM, An SY, Lee BC. The effect of Hyulbuchuko-tang on a case with Deep Vein Thrombosis(DVT) and Intracranial Hemorrhage(ICH). Korean J Orient Int Med. 2009;30(2):438-449
13
13. Jung KH, Kim YS, Kang KS. Two Cases of Insomnia in Stroke Patients, Treated with Enhanced Blood Circulation. Korean J Orient Int Med. 2002;23(2):313-320
14
14. Cho EH, Kwon JN, Kim YG. Neuroprotective effect of Hyulbuchookau-tang on focal cerebral ischemia of the rats. J Korean Oriental Med. 2006;27(2):70-85
15
15. Cho EH, Kwon JN, Kim YG. Neuroprotective effects of Hyulbuchookau-tang on Global Cerebral Ischemia of the rats. J Korean Oriental Med. 2007;28(2):44-53
16
16. Park JH, Han YH, Jeon CY, Kim DW, Park SK, Lee CJH et al. The effects of Hyulbuchukotang (HCE) on the thrombosis related factors. Korean J Orient Int Med. 2000;21(5):819-827
17
17. Choi YK, Go JC, Baek EK, Hong ES, Han JW, Park SK et al. Effects of Hyeolbuchukeo-tang on LDL oxidation in macrophage cell. Korean J Orient Int Med. 2002;23(3):406-414
18
18. Han JM, Ko CB, Park CM, Jeoung MS, Park LK, Lee KN. Effects of Hyeolbuchukeo-tang (Xiefuzhuyu-tang) on NO production in aortic vascular smooth muscle cells. J Korean Oriental Med. 2002;23(2);19-27
19
19. Hankey GJ, Eikelboom JW. Aspirin resistance. Lancet. 2006;367(9510):606-617
20
20. Rondondi N, bauer DC. Assessing the risk/ benefit profile before recommending aspirin for the primary prevention of cardiovascular events. Am J Med. 2004;117(7):528-530
21
21. Cybulsky MI, Gimbrone MA. Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis. Science. 1991; 251(4995):788-791
22
22. Weissberg PL, Bennett MR. Atherosclerosis - an inflammatory disease. New Engl J Med. 1999; 340(2):115-126
23
23. 오구택. 형질전환모델동물을 이용한 동맥경화증 의 연구 및 치료제 개발. 생화학분자생물학뉴스 2002;22(1):12-21
24
24. 조홍근, 장양수. Small dense LDL과 동맥경화증. 한국지질동맥경화학회지. 2003;13(2):333-339
25
25. Anber V, Griffin BA, McConnell M, Packard CJ, Shepherd J. Influence of plasma lipid and LDL-subfraction profile on the interaction between low density lipoprotein with human arterial wall proteoglycans. Atherosclerosis. 1996;124(2):261-271
26
26. Packard CJ. Triacylglycerol-rich lipoproteins and the generation of small, dense low-density lipoprotein, Biochem Soc Trans. 2003;31(5): 1066-1069
27
27. Anuurad E, Shiwaku K, Enkhmaa B, Nogi A, Kitajima K, Yamasaki M, Yamane Y. Ethnic differences in the formation of small LDL particles in Asians: a comparison of Koreans, Japanese and Mongolians. Eur J Clin Invest. 2004;34(11):738-746
28
28. Cho HK, Shin G, Ryu SK, Jang Y, Day SP, Stewart G, et al. Regulation of small dense LDL concentration in Korean and Scottish men and women. Atherosclerosis. 2002;164(1):187-193
29
29. Zhang SH, Reddick RL, Piedrahita JA, Maeda N. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science. 1992;258(5081):468-471
30
30. Plump AS, Smith JD, Hayek T, Aalto-Setala K, Walsh A, Verstuyft JG, et al. Severe hypercholesterolemia and atherosclerosis in apolipoprotein E deficient mice created by homologous recombination in ES cells. Cell. 1992;71(2): 343-353
31
31. Zhou X, Stemme S, Hansson GK. Evidence for a local immune response in atherosclerosis. CD4+ T cells infiltrate lesions of apolipoprotein- E -deficient mice. Am J Pathol. 1996;149(2): 359-366
32
32. Roselaar SE, Kakkanathu PX, Daugherty A. Lymphocyte populations in atherosclero- tic lesion of ApoE-/- and LDL receptor-/- mice. Decreasing density with disease progression. Arterioscler Thromb Vasc Biol. 1996;16(8): 1013-1018
33
33. Skoglund-Anderson C. Influence of common variants in the CETP, LPL, HL and APO E genes on LDL heterogeniety in healthy, middle-aged men. Atherosclerosis. 2003;167(2);311-317
34
34. Friend M, Vucenik I, Miller M. Platelet responsiveness to aspirin in patients with hyperlipidaemia. BMJ. 2003;326(7380):82-83
35
35. Karepov V, Tolpina G, Kuliczkowski W, Serebruany V. Plasma triglycerides as predictors of platelet responsiveness to aspirin in patients after first ischemic stroke. Cerebrovasc Dis. 2008;26(3):272-276
36
36. Comerota AJ. Effect on platelet function of cilostazol, clopidogrel, and aspirin, sach alone or in combination. Atheroscler Suppl. 2005;6(4):13-19
37
37. An YS, An TW, Kang HJ, Lee YH, Lim YK. The effect of herbal-acupuncture with Moutan Cortex Radicis extract. Journal of Meridian & Acupoint. 2009;26(1):85-109
38
38. Ridker PM, Silvertown JD. Inflammation, C-reactive protein and atherothrombosis. J Periodontol. 2008;79(8 suppl);1544-1551
- Downloaded
- Viewed
- 0KCI Citations
- 0WOS Citations
Other articles from this issue
- Study on Pulse Simulator of Oriental Medicine for Objective Structured Clinical Examination (OSCE)
- Study of Toxicity Presence Classification about Herbal Diet in Tang-aec-pyeon of Dong-ui-bo-gam
- A Comparison Study of Factors of Willingness to Use Traditional Medicine between Korean, Chinese and Taiwanese
- A Structural Analysis of Sanghanron by Network Model -Centered on Symptoms and Herbs of Taeyangbyung Compilation in Sanghanron-
- Single Dose Oral Toxicity and Genotoxicological Safety Study of Ssanghwa-tang Fermented with Lactobacillus acidophyllus
- Some Guidelines for Academic Sample Survey Studies in Korea Traditional Medicine
- Determinants of the Utilization of Oriental Medical Services by the Elderly
- Effects of KHchunggan-tang on the Nonalcoholic Fatty Liver Disease in Palmitate-induced Cellular Model
- Developing a Health Informatics Conceptual Framework for Representing Clinical Findings in Traditional East Asian Medicine
- Effects of Chunghyuljihwang-tang on Phenylhydrazine-induced Hemolytic Anemia in Rats
- Evaluation of Antioxidant Activity of Solvent Fractions of Angelica gigas Root Using TOSC Assay
- The Effects of Persicae Semen Herbal-acupuncture at GB34 (Yangneungcheon) on a Rat Model of Hyperlipidemia
- Effects of Concurrent Administration of Hyeolbuchukeo-tang and Aspirin on Atherosclerosis in the ApoE^((-/-)) Mouse
- Effects of Angelicae Pubescentis Radix Water Extract on Immune Property in RAW 264.7 Macrophages
- more
Recommanded Articles
This website recommended the use the Chrome browser for journal website.