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- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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Anti-Myelosuppression Effects of Korean Red Ginseng in SD Rat Injected with 5-fluorouracil
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2012, v.33 no.2, pp.47-55
(Daejeon Oriental Hospital of Oriental Medical College of Daejeon University)
(Daejeon Oriental Hospital of Oriental Medical College of Daejeon University)
(Daejeon Oriental Hospital of Oriental Medical College of Daejeon University)
(Daejeon Oriental Hospital of Oriental Medical College of Daejeon University)
(Daejeon Oriental Hospital of Oriental Medical College of Daejeon University)
(Daejeon Oriental Hospital of Oriental Medical College of Daejeon University)
(Daejeon Oriental Hospital of Oriental Medical College of Daejeon University)
(Daejeon Oriental Hospital of Oriental Medical College of Daejeon University)
(Daejeon Oriental Hospital of Oriental Medical College of Daejeon University)
Hye-Jung,
P.
, Jong-Min,
H.
, Hyeong-Geug,
K.
, Min-Kyung,
C.
, Jin-Seok,
L.
, &
(2012). Anti-Myelosuppression Effects of Korean Red Ginseng in SD Rat Injected with 5-fluorouracil. Journal of Korean Medicine, 33(2), 47-55.
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Abstract
Objectives: This study aimed to investigate the preventive effect of red ginseng (RG) on 5-fluorouracil (5-FU)-induced side effects focusing on myelosuppression. Methods: Rats (n = 50) were divided into five groups, nave, control (ip, 5-FU injection of 150 mg/kg), and RG pre-treatment (po, 25, 50 and 100 mg/kg for 5 days before 5-FU injection). On the 7th day after 5-FU injection, we evaluated the effects using peripheral hematological parameters, colony-forming assay, cytokine levels and histopatho- logical finding. Results: The peripheral white blood cell and the differential count were dramatically suppressed by 5-FU, while RG (50 and 100 mg/kg) treatment significantly improved total white blood cell, neutrophil, lymphocyte and platelet counts. Also, RG (100 mg/kg) pre-treatment significantly increased the number of CFU-GM colony compared with the control group. RG pre-treatment also ameliorated the histopathological damage in bone marrow, spleen, stomach and small intestine tissue. Conclusions: These results demonstratethat Korean RG has preventive effects against 5-FU-induced myelotoxicity and gastrointestinal damage.
- keywords
- Red ginseng, 5-fluorouracil, Myelosuppression, Side effect, Chemotherapy
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