- P-ISSN 1010-0695
- E-ISSN 2288-3339
- Log In/Sign Up
- P-ISSN1010-0695
- E-ISSN2288-3339
Article Detail
Home > Article Detail
Screening of Preventive Effects of Herbal Prescriptions in Rat Model of Arterial Thrombosis Induced by Ferric Chloride
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2013, v.34 no.2, pp.20-28
https://doi.org/10.13048/jkm.13003
&
(2013). Screening of Preventive Effects of Herbal Prescriptions in Rat Model of Arterial Thrombosis Induced by Ferric Chloride. Journal of Korean Medicine, 34(2), 20-28, https://doi.org/10.13048/jkm.13003
- Downloaded
- Viewed
Abstract
Objectives: This study examined the effects of 8 types of herbal prescriptions prescribed to alleviate dementia symptoms in a rat model of arterial thrombosis induced by ferric chloride (FeCl3). Methods: Thirty minutes before 35% FeCl3 treatment, SD rats were intraperitoneally injected with the 8 types of herbal prescriptions, respectively. We tested the effects of the herbal prescriptions on time to occlusion (TTO) in an arterial thrombosis model using a laser Doppler flow meter. In addition, thrombus weight (TW) and collagen fiber damages were evaluated in the same condition. Results: Herbal prescriptions showed the following rank-order based on their TTO: Chong-myung-tang (CMT) > modified Jangwonhan 02 (LMK02) > Toki-shakuyaku-san (TSS) ≥ Oren-gedoku-to (OGT) ≥ Yokukansan (YKS). In particular, CMT (100 mg/kg, i.p.) and LMK02 (100 mg/kg, i.p.) delayed the TTO the most (14.83 ± 0.98 and 13.67 ± 1.03 min, respectively) compared with the vehicle group (7.95 ± 0.78 min, P<0.001). In addition, CMT, LMK02, and OGT treatment (0.63 ± 0.01, 0.66 ± 0.02 and 0.67 ± 0.01 mg/mm, respectively) significantly reduced thrombus weight compared with the vehicle treatment (0.78 ± 0.03, P<0.001) and also alleviated collagen fiber damage (CMT; 28.40 ± 2.22%, LMK02; 30.79 ± 4.07%, OGT; 26.20 ± 1.48%) in the vessels injured by FeCl3. Therefore, CMT and LMK02 showed the greatest preventive activity in rat model of arterial thrombosis induced by FeCl3. Conclusions: These results provide experimental evidence for traditional use of herbal prescriptions, suggesting that CMT and LMK02 extracts could be used to prevent vascular injury and thrombosis in the early stages of dementia.
- keywords
- Herbal prescriptions, ferric chloride, vascular injury, thrombosis
Reference
1
1. Decarli C. Vascular factors in dementia: anoverview. J Neurol Sci. 2004;226(1-2):19-23.
2
2. Duron E, Hanon O. Vascular risk factors,cognitive decline, and dementia. Vasc HealthRisk Manag. 2008;4(2):363-81.
3
3. Quintanilla RA, Orellana JA, von Bernhardi R.Understanding Risk Factors for Alzheimer'sDisease: Interplay of Neuroinflammation,Connexin-based Communication and OxidativeStress. Arch Med Res. 2012;43(8):632-44.
4
4. Marchesi VT. Alzheimer’s dementia begins as adisease of small blood vessels, damaged byoxidative-induced inflammation anddysregulated amyloid metabolism: implicationsfor early detection and therapy. FASEB J.2011;25(1):5-13.
5
5. Gorelick PB, Scuteri A, Black SE, Decarli C,Greenberg SM, Iadecola C, et al. Vascularcontributions to cognitive impairment anddementia: a statement for healthcareprofessionals from the American HeartAssociation/American Stroke Association.Stroke. 2011;42(9):2672-713.
6
6. Howland RH. Drug therapies for cognitiveimpairment and dementia. J Psychosoc NursMent Health Serv. 2010;48(4):11-4.
7
7. Hiramatsu M, Takiquchi O, Nishiyama, Mori H.Cilostazol prevents amyloid βpeptide25-35-induced memory impairment andoxidative stress in mice. Br J Pharmacol.2010;161(8):1899-912.
8
8. Ryu KH, Han HY, Lee SY, Jeon SD, Im GJ,Lee BY, et al. Ginkgo biloba extract enhancesantiplatelet and antithrombotic effects ofcilostazol without prolongation of bleeding time.Thromb Res. 2009;124(3):328-34.
9
8. Hwang GH, Kim BH, Shin JW, Shim ES, LeeDE, Lee SY, et al. Effects of Woo-Gui-Um onA?? Toxicity and Memory Dysfunction in Mice.J. Korean Oriental Med. 2009;30(3): 1-14.
10
9. Furie B, Furie BC. Thrombus formation in vivo.J Clin Invest. 2005;115(12):3355-62.
11
10. Kurz KD, Maiin BW, Sandusky GE. Rat modelof arterial thrombosis induced by ferric chloride.Thromb Res. 1990;60(4):269-80.
12
11. Lee IS, Jeon WK. Optimization of ferric chlorideinduced carotid artery thrombosis model in a rat:Effect of Ginkgo biloba extracts. Korean J ClinLab Sci. 2011;43(4):179-87.
13
12. Eckly A, Hechler B, Freund M, Zerr M,Cazenave JP, Lanza F, et al. Mechanismsunderlying FeCl3-induced arterial thrombosis. JThromb Haemost. 2011:9(4):779-89.
14
13. Williams RJ, Spencer JP. Flavonoids, cognition,and dementia: actions, mechanisms, and potentialtherapeutic utility for Alzeheimer disease. FreeRadic Biol Med. 2012; 52(1):35-45.
15
14. Hogan DB. Progress update: pharmacologicaltreatment of Alzheimer’s disease. NeuropsychiatrDis Treat. 2007;3(5):569-78.
16
15. Heo EJ, Kang JS, Kang HW, Jeon WK.Evaluation on the Quality of research field withtraditional herbal prescriptions for dementiatherapy. J of Oriental Neuropsychiatry.2012;23(1):93-116.
17
16. Wang X, Smith PL, Hsu MY, Oqletree ML,Schumacher WA. Murine model of ferricchloride-induced vena cava thrombosis: evidencefor effect of potato carboxypeptidase inhibitor.J Thromb Haemost. 2006;4(2):403-10.
18
17. Kim SK, Jeon WK. Effects of ModifiedJe-Ho-Tang on Ferric Chloride-induced Thrombosis in a Rat Model and of PeripheralCirculatory Disturbance in a Mouse Model. JKorean Soc Appl Biol Chem. 2010;53(6):842-46.
19
18. Morris RA, Dubielzig RR. Light-microscopyevaluation of zonular fiber morphology in dogswith glaucome: secondary to lens displacement.Vet Ophthalmol. 2005;8(2):81-4.
20
19. Konstantinides S, Schafer K, Thinnes T,Loskutoff DJ. Plasminogen activator inhibitor-1and its cofactor vitronectin stabilize arterialthrombi after vascular injury in mice.Circulation. 2001;103(4):576-83.
21
20. Woollard KJ, Sturgeon S, Chin-Dusting JP,Salem HH, Jackson SP. Erythrocyte hemolysisand hemoglobin oxidation promote ferricchloride-induced vascular injury. J Biol Chem.2009;284(19):13110-8.
22
21. Honjo K, Black SE, Verhoeff NP. Alzheimer’sdisease, cerebrovascular disease, and the β-amyloid cascade. Can J Neurol Sci.2012;39(6):712-28.
23
22. Adams M, Gmunder F, Hamburger M. Plantstraditionally used in age related brain disorders-Asurvey of ethnobotanical literature. JEthnopharmacol. 2007;113(3):363-81.
24
23. Kim CW, Yun JW, Bae IH, Park YH, Jeong YS,Park JW, et al. Evaluation of anti-platelet andanti-thrombotic effects of cilostazol withPFA-100 (R) and Multiplate (R) whole bloodaggregometer in vitro, ex vivo andFeCl(3)-induced thrombosis models in vivo.Thromb Res. 2011;127(6):565-70.
25
24. Lee MR, Yun BS, Park SY, Ly SY, Kim SN,Han BH, et al. Anti-amnesic effect ofChong-myung-tang on scopolamine-inducedmemory impairments in mice. J Ethnopharmacol.2010;132(1):70-4.
26
25. Kim HM, Lee YJ, Lyu YS. Inhibition oflipopolysaccharide plus substance P-inducedtumor necrosis factor-α production fromastrocytes by Chongmyung-Tang. JEthnopharmacol. 1999;66(3):295-300.
27
26. Seo JS, Yun JH, Baek IS, Leem YH, Kang HW,Cho HK, et al. Oriental medicine Jangwonhwanreduces Aβ(1 42) level and β-amyloiddeposition in the brain of Tg-APPswe/PS1dE9mouse model. J Ethnopharmacol.2010;128(1):206-12.
28
27. Seo JS, Jung EY, Kim JH, Lyu YS, Han PL,Kang HW. A modified preparation (LMK03) ofthe oriental medicine Jangwonhwan reduces Aβ142 level in the brain of Tg-APPswe/PS1dE9mouse model of Alzheimer disease. JEthnopharmacol. 2010;130(3):578-85.
29
28. Jesky R, Hailong C. Are herbal compounds thenext frontier for alleviating learning and memoryimpairments? An integrative look at memory,dementia and the promising therapeutics oftraditional Chinese medicine. Phytother Res.2011;25(8):1105-18.
- Downloaded
- Viewed
- 0KCI Citations
- 0WOS Citations
Other articles from this issue
- Correlation between Abdominal Fat Distribution and Abdominal Temperature in Korean Premenopausal Obese Women
- Lonicerae Flos Inhibits Cigarette-induced Lung Inflammatory Responses in Animal Model of Chronic Obstructive Pulmonary Disease
- Screening of Preventive Effects of Herbal Prescriptions in Rat Model of Arterial Thrombosis Induced by Ferric Chloride
- Literature Review on Biological Effects of Gyejibokryeong-hwan against Gynaecological Diseases
- A Study on the Strategic Vitalization Plan of Korean Integrated Medical Tourism
- Anti-thrombotic Effects of Modified Jeho-tang using a FeCl3-induced Carotid Arterial Thrombosis Model
- Successful Treatment of Two Patients with Immune Thrombocytopenic Purpura Using Herbal Decoction
- more
Recommanded Articles
This website recommended the use the Chrome browser for journal website.