- P-ISSN 1010-0695
- E-ISSN 2288-3339
- Apply for Authority
- P-ISSN1010-0695
- E-ISSN2288-3339
Article Detail
Home > Article Detail
Introduction of evidence-based practical medicine through safety classification for herbal medicine(1)
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2014, v.35 no.1, pp.114-123
&
(2014). Introduction of evidence-based practical medicine through safety classification for herbal medicine(1). Journal of Korean Medicine, 35(1), 114-123.
- Downloaded
- Viewed
Abstract
Objectives: Evidence-based medicine(EBM) advocates the use of up-to-date “best” scientific evidence from health care research as the basis for making medical decisions. EBM also has been applied to traditional Korean medicine(TKM), especially in the field of safety. Recently, the standard prescription for TKM by Korea Institute of Oriental Medicine was published based on toxic index from various toxicity tests. However, there are some limitations when the results from the study based on EBM are applied in clinics. To overcome these imitations, the term “evidence-based practical medicine” was developed and defined as clinically applicable results from the study based on EBM. And safety classification for TKM was suggested as an example of evidence-based practical medicine. Methods: For safety classification for TKM, the data for LD50(50% lethal dose), which was transformed to theoretical LD1(1% lethal dose), was analyzed as one of tools for EMB study and divided by maximum dose used in clinics. Results and Conclusions: As a result, human equivalent dose(HED)-based MOS(margin of safety) for korean traditional medicine was calculated and used for safety classification with 5 categories. These categories would be helpful for oriental medicine clinicians to decide the increase and decrease of dosage according to various factors such as patient’s sensitivity, potential toxicity of herbal medicines, clinician’s experience for better cure. Thus, this safety classification provides some evidences enough that evidence-based practical medicine should be not the same with EBM and defined differently from EBM.
- keywords
- Herbal medicine, Safety classification, Evidence-based practical medicine
Reference
1
1. Korea Institute for oriental medicine. standard prescription for Korean medicine. Medicine information. 2011, 2013
2
2. Lee SD, Park YC. Toxicology for herbal medicine I. Korean Studies Information(Ltd.). 2012.
3
3. KFDA. Research about management system of herbal medicine classification for safety. 2012.
4
4. Sackett DL, Rogenberg WM. Gray JA. Evidence-based medicine: what it is and what it isn't. BMJ. 1996;312(7023):71-2.
5
5. An HS. Application and development of Evidence-based Medicine. The korean Journal of pancreas and Biliary Tract. 2013;18(1): suppl 1.
6
6. Upshur RE, VanDenKerkhof EG, Goel V. “Meaning and measurement: an inclusive model of evidence in health care”. J Eval Clin Pract. 2001;7(2):916.
7
7. Park YS, Lee SD. Evidence-based approach for herbal medicine-safety classification: Human equivalent dose-based the margin of safety. 2013:17(3):1-12.
8
8. Reagan-Shaw S, Nihal M, Ahmad N. Dose translation from animal to human studies revisited. Journal of the Federation of American Societies for Experimental Biology. 2008;22:659661.
9
9. Jiang GZ, Chen L. New research progress of toxicity of aristolochic acid in traditional Chinese medicine. Chinese Agricultural Science Bulletin. 2008;24:8487.
10
10. Kang SK, Song KB. Detection of aristolochic acid from herbal medicine marketed, J. Korean Soc. Food Sci. Nutr. 2003;32(7):1164-1167.
11
11. Jiang X, Li L, Wang WH, Wang JH, Gao HM, Wang ZM, Toxicologically studies of raw radix aristolochiae and it’s processed product. Chinese Remedies and Clinics. 2006;6:485487.
12
12. Chinese Pharmacopoeia Commission. Pharmacopoeia of the People’s Republic of China. Beijing: China Medical Science Press. 2010.
13
13. Yaoxue T. Bulletin of Pharmacology. Beijing: China International Book Trading Corp. 1978-88;V.13-23.
14
14. Lee JY, Moon SS, Hwang BK. Isolation and antifungal activity of kakuol, a propiophenone derivative from Asarum sieboldii rhizome, Pest management science. 2005;61:821-825.
15
15. Kazunori H. Studies on anti-allergic components in the roots of Asiasarum sieboldii, Planta Med. 2005;60:124-127.
16
16. Pan HL, Zhi YT. Comparative Analysis of Volatile Oil Extracted from Asarum sieboldii Miq. by Steam Distillation and Ultrasoundassisted Extraction. Food Science. 2011;32(10) :190-193.
17
17. Committee of Text book for Herbal medicine. Herbal medicine. Dongmyeongsa. 2006;151-153.
18
18. Wei X., Fu Y, Wang H, Wang Y, Han Y, Sun K. The acute toxicity appraises of the Asarum heterotropoides Fr. Schmidt var. Mandshuricum (Maxim.) Kitag, Asarum sieboldii Miq. And Asarum sieboldii Miq. Var. Seoulense Nakai. Asia-Pacific Traditional Medicine. 2010;6:2325
- Downloaded
- Viewed
- 0KCI Citations
- 0WOS Citations
Other articles from this issue
- The Study for standardized Method of the Retention-Enema; For a Method of Experimental Study
- A Review of Romanized Prescription Nomenclature in the Journal of Korean Medicine
- Efficacy of Electroacupuncture with Dysphagia Caused by Stroke - Double-blind, Randomized Controlled Trial -
- Models and Representations of Formulas in Korean Medicine Information Systems
- A Comparison Study of Postural Control Measures Between Before and After Applying Temporomandibular Joint Balance Appliance-Golf (TBA-G) Using Balance Master System
- Study about the Status and Prevention of Oriental Medical Disputes
- Progress of Functional Food Market in Korea and Strategy of Korean Medicine
- Nationwide Study on the Characteristics of Patients Visiting and Using Korean Medical Facilities by Sex
- Relationship between Bone Age, Chronological Age, Anthropometric Parameters, and Diagnosed Pulse Rate on secondary sexual character development of child-Adolescence
- Usage of Medicinal Moxibustion for the improvement of Moxibustion Treatment Procedure
- Introduction of evidence-based practical medicine through safety classification for herbal medicine(1)
- Relation between Metabolic Syndrome and Obesity Pattern Identification Questionnaire in Middle-aged Health Check-up Examinees
- A Study for Effects of Metabolic Syndrome Care Program with Korean Medicine in Public Health Center
- Institutional Analysis on Organizational Changes of Korean Medicine Hospitals
- Study on the Development of a Standard Instrument of Diagnosis and Assessment for Spleen Qi Deficiency Pattern
- more
Recommanded Articles
This website recommended the use the Chrome browser for journal website.