- P-ISSN 1010-0695
- E-ISSN 2288-3339
- Apply for Authority
- P-ISSN1010-0695
- E-ISSN2288-3339
Article Detail
Home > Article Detail
Successful Outcome of Elderly Patients with Advanced Malignant Melanoma by Standardized Allergen-removed Rhus verniciflua Stokes Extract and Bojungikki-tang: Two Cases
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2014, v.35 no.4, pp.98-103
&
(2014). Successful Outcome of Elderly Patients with Advanced Malignant Melanoma by Standardized Allergen-removed Rhus verniciflua Stokes Extract and Bojungikki-tang: Two Cases. Journal of Korean Medicine, 35(4), 98-103.
- Downloaded
- Viewed
Abstract
Objectives: Advanced malignant melanoma (MM) has a poor prognosis, with an expected 2-year survival rate of 10to 20%. It has long been recognized as an immunogenic tumor, and is worse for elderly patients. Many studies havesuggested that herbal treatments improve immune functions, but few clinical studies have reported on this topic. Patients and History: We present two cases of female patients (72 and 77 years old, respectively) with advancedMM. The 72-year-old female patient was, at first, diagnosed with MM with multiple bone metastases. Shereceived resection of the primary lesion, but refused further chemotherapy. The 77-year-old female patient wasdiagnosed with cutaneous MM of the left heel, with suspicion of sentinel node lymphadenopathy; however, shealso refused any conventional treatment due to old age. Course of Therapy and Results: Both patients were exclusively treated with standardized allergen-removed Rhusverniciflua stokes (aRVS) extract combined with Bojungikki-tang (BT, Bu-Zhong-Yi-Qi-Tang in Chinese orHochu-ekki-to in Japanese). Both patients are still alive and doing well (Feb. 2014), demonstrating that the72-year-old patient has lived for 27 months and the 77-year-old patient has lived for 31 months without diseaseprogression since the aRVS and BT administration. Conclusion: We suggest that the combination of aRVS extract and BT could be a candidate for overcoming thecancer’s immunoediting process especially for elderly MM patients intolerant of conventional treatment.
- keywords
- Malignant melanoma, Aged, Rhus verniciflua Stokes, Bojungikki-Tang
Reference
1
1. Houghton AN, Polsky D. Focus on melanoma. Cancer Cell. 2002;2(4):275-8.
2
2. Soengas MS, Lowe SW. Apoptosis and melanoma chemoresistance. Oncogene. 2003;22(20):3138-51.
3
3. Macdonald JB, Dueck AC, Gray RJ, Wasif N, Swanson DL, Sekulic A, et al., Malignant melanoma in the elderly: different regional disease and poorer prognosis. Journal of Cancer. 2011;2:538-43.
4
4. Hegde UP, Grant-Kels JM, Metastatic melanoma in the older patient: special considerations. Clinics in Dermatology. 2013;31(3):311-6.
5
5. Kang CH,, Shin HK, Shim BS, Kim SH, Choi SH, et al. Experimental Studies on the Anti-angiogenesis and Anti-metastasis Effects of Ekong-san. Journal of Korean Traditional Oncology. 2006;11(1):41-54.
6
6. Lee SG, Ha JH. Antitumor and immunomodulatory effects of Ikongsan on murine melanoma-induced lung metastasis. Korean Journal of Oriental Medical Pathology. 1997;11(1):21-30.
7
7. Kwon SJ, Lee JH, Moon KD, Jeong IY, Ahn DU, Lee MK, et al. Induction of apoptosis by isoegomaketone from Perilla frutescens L. in B16melanoma cells is mediated through ROS generation and mitochondrial-dependent, -independent pathway. Food Chem Toxicol. 2013.
8
8. Nabeshima S, Murata M, Hamada M, Chong Y, Yamaji K, Hayashi J. Maturation of monocyte -derived dendritic cells by Hochu-ekki-to, a traditional Japanese herbal medicine. Int Immunopharmacol. 2004;4(1):37-45.
9
9. Cho S, Hong T, Kaneko A, Yoshino G, Sato N, Kikuchi K, et al. Evaluation of immunological effects of hochu-ekki-to (TJ-41) prophylactic administration in mice. Am J Chin Med. 2004;32(2):235-43.
10
10. Chae SY, Shin SH, Ha MH, Jo SK, Kim SH, Byun MW, et al. Effect of Bu - Zhong - Yi - Qi - Tang on Proliferation of T Cells. Journal of the Korean Society of Food Science and Nutrition. 2004;33(7):1085-91.
11
11. Jeong JS, Ryu BH, Kim JS, Park JW, Choi WC, Yoon SW. Bojungikki-tang for cancer-related fatigue: a pilot randomized clinical trial. Integr Cancer Ther. 2010;9(4):331-8.
12
12. Choi W, Jung H, Kim K, Lee S, Yoon S, Park J, et al. Rhus verniciflua Stokes against Advanced Cancer: A Perspective from the Korean Integrative Cancer Center. Journal of Biomedicine &Biotechnology. 2012;2012:874276.
13
13. Lee S, Kim K, Jung H, Cheon S, Kim S, Eo W, et al. Efficacy and Safety of Standardized Allergen-Removed Rhus verniciflua Stokes Extract in Patients with Advanced or Metastatic Pancreatic Cancer: A Korean Single-Center Experience. Oncology. 2011;81(5-6):312-8.
14
14. Choi W, An S, Kwon E, Eo W, Lee S. Impact of Standardized Allergen-Removed Rhus verniciflua Stokes Extract on Advanced Adenocarcinoma of the Ampulla of Vater: A Case Series. Evidence-based Complementary and Alternative Medicine : eCAM. 2013;2013:203168.
15
15. Satoh N, Sakai S, Kogure T, Tahara E, Origasa H, Shimada Y, et al. A randomized double blind placebo-controlled clinical trial of Hochuekkito, a traditional herbal medicine, in the treatment of elderly patients with weakness N of one and responder restricted design. Phytomedicine. 2005;12(8):549-54.
16
16. Kuroiwa A, Liou S, Yan H, Eshita A, Naitoh S, Nagayama A. Effect of a traditional Japanese herbal medicine, hochu-ekki-to (Bu-Zhong-Yi-Qi Tang), on immunity in elderly persons. Int Immunopharmacol. 2004;4(2):317-24.
17
17. Yamaoka Y, Kawakita T, Nomoto K. Protective effect of a traditional Japanese medicine Hochu-ekki-to (Chinese name: Bu-zhong-yiqi-tang), on the susceptibility against Listeria monocytogenes in infant mice. Int Immunopharmacol. 2001;1(9-10):1669-77.
18
18. Utsuyama M, Seidlar H, Kitagawa M, Hirokawa K. Immunological restoration and anti-tumor effect by Japanese herbal medicine in aged mice. Mechanisms of Ageing and Development. 2001;122(3):341-52.
19
19. Li T, Tamada K, Abe K, Tada H, Onoe Y, Tatsugami K, et al. The restoration of the antitumor T cell response from stress-induced suppression using a traditional Chinese herbal medicine Hochu-ekki-to (TJ-41:Bu-Zhong-Yi-Qi-Tang). Immunopharmacology. 1999;43(1):11-21.
20
20. Ahn KS, Lee KT, Jang SK, Jeong JC, Noh YS. Experimental Studies on the Immunomodulatory Effects of Ekong-san. Journal of the Institute of Oriental Medicine. 1999;2(-):15-29.
21
21. Lee SK, Jung HS, Eo WK, Lee SY, Kim SH, Shim BS. Rhus verniciflua Stokes extract as a potential option for treatment of metastatic renal cell carcinoma: report of two cases. Ann Oncol. 2010;21(6):1383-5.
22
22. Clemente CG, Mihm MC, Jr. Bufalino R, Zurrida S, Collini P, Cascinelli N. Prognostic value of tumor infiltrating lymphocytes in the vertical growth phase of primary cutaneous melanoma. Cancer. 1996;77(7):1303-10.
23
23. Quezada SA, Peggs KS. Exploiting CTLA-4, PD-1 and PD-L1 to reactivate the host immune response against cancer. British Journal of Cancer. 2013;108(8):1560-5.
24
24. Maio M. Melanoma as a model tumour for immuno-oncology. Annals of Oncology. 2012;23:10-4.
- Downloaded
- Viewed
- 0KCI Citations
- 0WOS Citations
Other articles from this issue
- The Effects of Phragmitis Rhizoma Herbal-acupuncture Solution on Inflammation in Human Mast Cells and Human Alveolar Epithelial Cell Lines - Phragmitis Rhizoma's Effects -
- Effect of Guibi-tang on Neuronal Apoptosis and Cognitive Impairment Induced by Beta Amyloid in Mice
- Effects of Acupuncture on Heart Rate Variabilityin Obese Premenopausal Korean Women
- Classification of the Efficacy of Herbal Medicine Alterations in Neuronal Hypoxia Models through Analysis of Gene Expression
- Perceived Health Status and Health Promoting Behaviors among University Students
- Determinants of Inpatients Satisfaction and Intent to Revisit Oriental Medical Hospitals
- Quantitative study of acupuncture manipulation of lifting-thrusting using an needle insertion-measurement system in phantom tissue
- The Identification of Aucklandiae Radix, Inulae Radix, Vladimiriae Radix and Aristolochiae Radix, Using Macroscopic, Microscopic and Physicochemical Methods
- Successful Outcome of Elderly Patients with Advanced Malignant Melanoma by Standardized Allergen-removed Rhus verniciflua Stokes Extract and Bojungikki-tang: Two Cases
- Management of Idiopathic Interstitial Pneumonia Treated only with Traditional Korean Medicine: a Case Report
- A Case Report of Improvement of Docetaxel-induced Fluid Retention in a Patient with Advanced Gastric Cancer using Herbal Decoction, Modified Bangkihwangki-tang
- Improvement of cancer bleeding in rectal cancer patient with a herbal decoction, Inhyungtang : A case report
- more
Recommanded Articles
This website recommended the use the Chrome browser for journal website.