- P-ISSN 1010-0695
- E-ISSN 2288-3339
- Apply for Authority
- P-ISSN1010-0695
- E-ISSN2288-3339
Article Detail
Home > Article Detail
Review on the Efficacy and Safety of Mahuang and Ephedrine in the Treatment of Obesity -Focused on RCT-
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2017, v.38 no.3, pp.170-184
https://doi.org/10.13048/jkm.17034
&
(2017). Review on the Efficacy and Safety of Mahuang and Ephedrine in the Treatment of Obesity -Focused on RCT-. Journal of Korean Medicine, 38(3), 170-184, https://doi.org/10.13048/jkm.17034
- Downloaded
- Viewed
Abstract
Objectives: The objective of this study was to summarize randomized clinical trials (RCTs) that have assessed efficacy and safety of mahuang and ephedrine on treatment of obesity and to propose better process of study. Methods: NLM Medline (pubmed), the Cochrane library, Scopus, Science Direct, RISS, KISS were systemically searched for clinical trials investigating the efficacy, safety of mahuang and ephedrine on treatment of obesity from 2000 to 2017. Results: 16 RCTs met all the inclusion criteria. In most reports, mahuang and ephedrine significantly reduced body weight, body fat mass. There were no serious adverse events associated with mahuang and ephedrine in all studies. Conclusions: In appropriate dose of mahuang and ephedrine for healthy adult was safe, and weight loss effect of mahuang and ephedrine was better than control group. Improved clinical practice guidelines should be developed for safe use of mahuang and ephedrine.
- keywords
- Mahuang, ephedrine, efficacy, safety, obesity, weight loss
Reference
1
1. World Health Organization. Reducing Risks -Promoting healthy life. World Health Report 2002, Geneva, WHO 2002.
2
2. Ministry of Health and Welfare. Korea Centers for Disease Control and Prevention. Korea Health Statistics 2014:Korea National Health and Nutrition Examination Survey (KNHANES Ⅵ-2).
3
3. Kopelman P. Health risks associated with overweight and obesity. Obesity Reviews. 2007;8(1):13-17.
4
4. Kopelman PG. Obesity as a medical problem. Nature. 2000;404(6778):635-643.
5
5. Lee KW. Correct Obesity Drug Therapy. Korean Journal of International Medicine. 2009;77(4):971-976.
6
6. Lee TH. Treatment of Obesity. Korean Journal of Medicine. 2001;61(3):227-233.
7
7. Song YK, Lim HH. Clinical Application of Ma Huang in the Obesity Treatment. Journal of Society of Korean Medicine for Obesity Research. 2007: 7(1):1-7.
8
8. Hwang MJ, Shin HD, Song MY. Literature review of herbal medicines on treatment of obesity since 2000-Mainly about Ephedra herba. Journal of Society of Korean Medicine for Obesity Research. 2007;7(1):39-54.
9
9. Jeong JW, Cho SW. Trend research of the human body-Oriented obesity studies on Korean medicine. Journal of Korean Medicine Rehabilitation. 2016;26(1):49-61.
10
10. Lim SY, Park SW, Joo JH, Kim SR, Kim DJ, Choi WS. The effects of Taeeumjowui-tang (Taiyintiaowei-tang) on obesity in sasang constitution. The Journal of East-West Medicine. 2012;37(4):109-116.
11
11. Professors of formula study of Korean Medicine School. Clinical Traditional Herbalogy. Seoul;Yeong-lim Press. 2016:236
12
12. Andraws R, Chawla P, Brown DL. Cardiovascular effects of ephedra alkaloids: a comprehensive review. Progress in Cardiovascular Diseases. 2005;47(4): 217-25.
13
13. Lee MK, Cheng BW, Che CT, Hsieh DP. Cytotoxicity assessment of Ma-huang (Ephedra)under different conditions of preparation. Toxicol Sci. 2000;56(2):424-30.
14
14. Jang IS, Hwang EH. The Need for Clinical Practice Guidelines in Usage of Mahuang in Weight Loss. Journal of Society of Korean Medicine for Obesity Research. 2007:(1):23-29.
15
15. Department of Health and Human Services, Agency for Healthcare Research and Quality, Shekelle P, Hardy ML, Morton SC, Maglione M, Suttorp M, et al. Ephedra and ephedrine for weight loss and athletic performance enhancement:Clinical efficacy and side effects. Available at:URL:http://www.fda.gov/OHRMS/DOCKETS/98fr/95n-0304-bkg0003-ref-07-01-index.htm. Accessed June, 2007.
16
16. Kim HJ, Han CH, Lee EJ, Song YK, Shin BC, Kim YK. A clinical practice guideline for Ma-huang(Ephedra sinica) prescription in obesity. Journal of Society of Korean Medicine for Obesity Research. 2007;7(2):27-37.
17
17. Liu AG, Smith SR, Fujioka K, Greenway FL. The effect of leptin, caffeine/ephedrine, and their combination upon visceral fat mass and weight loss. Obesity. 2013;21(10): 1991-1996.
18
18. Kim HJ, Park JM, Kim JA, Ko BP. Effect of Herbal Ephedra sinica and Evodia rutaecarpa on Body Composition and Resting Metabolic Rate:A Randomized, Double-blind Clinical Trial in Korean Premenopausal Women. Journal of Acupuncture and Meridian Studies. 2008;1(2):128-138.
19
19. Hackman RM, Havel PJ, Schwartz JH, Rutledge JC, Watnik MR, Nocite EM, et al. Multinutrient supplement containing ephedra and caffeine causes weight loss and improves metabolic risk factors in obese women: A randomized controlled trial. International Journal of Obesity. 2006;30(10):1545-1556.
20
20. Vukovich MD, Schoorman R, Heilman C, Jacob P, Benowitz NL. Caffeine-herbal ephedra combination increases resting energy expenditure, heart rate and blood pressure. Clinical and Experimental Pharmacology and Physiology. 2005;32(1-2):47-53.
21
21. Haller CA, Jacob P, Benowitz NL. Short-term metabolic and hemodynamic effects of ephedra and guarana combinations. Clinical pharmacology and therapeutics. 2005;77(6):560-71.
22
22. McBride BF, Karapanos AK, Krudysz A, Kluger J, Coleman CI, White CM. Electrocardiographic and hemodynamic effects of a multicomponent dietary supplement containing ephedra and caffeine: a randomized controlled trial. Journal of American Medical Association. 2004;291(2):216-21.
23
23. Hioki C, Yoshimoto K, Yoshida T. Efficacy of bofu-tsusho-san, an oriental herbal medicine, in obese Japanese women with impaired glucose tolerance. Clinical and experimental pharmacology & physiology. 2004;31(9):614-9.
24
24. Haller CA, Jacob P, Benowitz NL. Enhanced stimulant and metabolic effects of combined ephedrine and caffeine. Clinical pharmacology and therapeutics. 2004;75(4):259-73.
25
25. Greenway FL, Jonge L, Blanchard D, Frisard M, Smith SR. Effect of a dietary herbal supplement containing caffeine and ephedra on weight, metabolic rate, and body composition. Obesity Research. 2004;12(7):1152-1157.
26
26. Coffey CS, Steiner D, Baker BA, Allison DB. A randomized double-blind placebo-controlled clinical trial of a product containing ephedrine, caffeine, and other ingredients from herbal sources for treatment of overweight and obesity in the absence of lifestyle treatment. International Journal of Obesity. 2004;28(11):1411-1419.
27
27. Kalman D, Incledon T, Gaunaurd I, Schwartz H, Krieger D. An acute clinical trial evaluating the cardiovascular effects of an herbal ephedra-caffeine weight loss product in healthy overweight adults. International journal of obesity and related metabolic disorders. journal of the International Association for the Study of Obesity. 2002:26;363-1366.
28
28. Boozer CN, Daly PA, Homel P, Solomon JL, Blanchard D, Nasser JA, et al. Herbal ephedra/caffeine for weight loss: a 6-month randomized safety and efficacy trial. International journal of obesity and related metabolic disorders. journal of the International Association for the Study of Obesity. 2002;26(5), 593-604.
29
29. Zaragoza RM, Lonngi G, Ortiz RA, Huerta DR. Comparison of two formulations of d-norpseudoephedrine and placebo in obese patients treated during six months. Medicina Interna de Mexico. 2001:17(6);260-71.
30
30. Boozer CN, Nasser JA, Heymsfield SB, Wang V, Chen G, Solomon JL. An herbal supplement containing Ma Huang-Guarana for weight loss:a randomized, double-blind trial. International journal of obesity and related metabolic disorders. journal of the International Association for the Study of Obesity. 2001:25(3);316-24.
31
31. Molnar D, Torok K, Erhardt E, Jeges S. Safety and efficacy of treatment with an ephedrine/caffeine mixture. The first double-blind placebo-controlled pilot study in adolescents. International journal of obesity and related metabolic disorders. journal of the International Association for the Study of Obesity. 2000: 24(12);1573-8.
32
32. Kalman DS, Colker CM, Shi Q, Swain MA. Effects of a weight-loss aid in healthy overweight adults: Double-blind, placebo-controlled clinical trial. Current Therapeutic Research -Clinical and Experimental. 2000:61(4);199-205.
33
33. Jang IS, Yang CS, Hwang EH. The need for clinical practice guidelines in usage of Mahuang in weight loss. Journal of Society of Korean Medicine for Obesity Research. 2007:7(1):23-29.
- Downloaded
- Viewed
- 0KCI Citations
- 0WOS Citations
Other articles from this issue
- A Feasibility Study about Change of Ryodoraku Characteristics Caused by Treadmill Exercise Test
- Conventional Western Medicine and Complementary and Alternative Medicine on Leg Cramps: A Literature Review
- The Effect of Angelica gigas Nakai Extract and Bacillus Polyfermenticus KJS-2 on Atopic Dermatitis induced by DNCB in mice
- Inhibition of gene associated with Dyslipidemia and Antioxidative Effect of Artemisia iwayomogi, Curcumae Radix and Raphani Semen(ACR) on HepG2 cell model
- Effect of Sochungryong-tang Extract on Osteoclast Differentiation and Bone-pit Formation
- Survey of Korean Medicine Military Doctors for Establishing Clinical Evidence of Korean Medicine Treatment in Military Medical Service
- A Clinical Research about Herbal Cosmetics Containing Caffeic acid phenethyl ester Isolated from Vespae Nidus on the Whitening Effects
- Effects of Korean Medicine on Postural Instability and Gait Difficulty in Patient with Parkinsonism: Retrospective Study
- The trends of duplicate publication in Korean Medical journals.
- Preliminary Study to Develop the Korean Medical Pathologic Aging Scale and Korean Medical Pattern Identification for Dementia
- Analysis of Existing Guidelines and Randomized, Controlled, Clinical Trials for Development of [Guideline of Clinical Trial with Herbal Medicinal Product for gastric cancer]
- E-mail survey on the current status of clinical practice and activation measures for Korean medicine in stroke care
- A Study for effectiveness of School Doctor Program in Korean Medicine
- Review on the Efficacy and Safety of Mahuang and Ephedrine in the Treatment of Obesity -Focused on RCT-
- A Study on the Severity Classification in the KDRG-KM (Korean Diagnosis-Related Groups – Korean Medicine)
- more
Recommanded Articles
This website recommended the use the Chrome browser for journal website.