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- E-ISSN 2288-3339
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- P-ISSN1010-0695
- E-ISSN2288-3339
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Cardiac Safety Assessment of Medicinal Herbal Formulas Using hERG-HEK 293 cell
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2019, v.40 no.2, pp.94-105
https://doi.org/10.13048/jkm.19020
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(2019). Cardiac Safety Assessment of Medicinal Herbal Formulas Using hERG-HEK 293 cell. Journal of Korean Medicine, 40(2), 94-105, https://doi.org/10.13048/jkm.19020
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Abstract
Objectives: The correlation between medicinal herbal formulas and a risk of cardiotoxicity has been controversial. Thus, this study investigated cardiac safety assessment of 52 most commonly used medicinal herbal formulas. Methods: We evaluated the in vitro effects of medicinal herbal formulas on recombinant human embryonic kidney 293 (HEK 293) cell line expressing human ether-a-go-go-related gene (hERG) potassium channel. Results and Conclusion: Our results demonstrated that all of 52 medicinal herbal formulas did not show inhibition of hERG current in hERG-HEK 293 recombinant cells. In conclusion, these safety data suggest that 52 medicinal herbal formulas were not associated with an increased risk of cardiotoxicity in hERG-HEK 293 recombinant cells.
- keywords
- Medicinal herbal formulas, Korea traditional medicine, cardiac safety, cardiotoxicity, hERG potassium channel
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