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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

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hERG 칼륨 채널 매개성 HEK 293 세포를 이용한 한약 처방의 심장 독성 평가 연구

Cardiac Safety Assessment of Medicinal Herbal Formulas Using hERG-HEK 293 cell

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2019, v.40 no.2, pp.94-105
https://doi.org/10.13048/jkm.19020
최수산나 (한국한의학연구원)
권오빈 (대구경북첨단의료산업진흥재단)
이시온 (대구경북첨단의료산업진흥재단)
서창섭 (한국한의학연구원)
신현규 (한국한의학연구원)
최수산나, 권오빈, 이시온, 서창섭, & 신현규. (2019). hERG 칼륨 채널 매개성 HEK 293 세포를 이용한 한약 처방의 심장 독성 평가 연구. 대한한의학회지, 40(2), 94-105, https://doi.org/10.13048/jkm.19020
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Abstract

Objectives: The correlation between medicinal herbal formulas and a risk of cardiotoxicity has been controversial. Thus, this study investigated cardiac safety assessment of 52 most commonly used medicinal herbal formulas. Methods: We evaluated the in vitro effects of medicinal herbal formulas on recombinant human embryonic kidney 293 (HEK 293) cell line expressing human ether-a-go-go-related gene (hERG) potassium channel. Results and Conclusion: Our results demonstrated that all of 52 medicinal herbal formulas did not show inhibition of hERG current in hERG-HEK 293 recombinant cells. In conclusion, these safety data suggest that 52 medicinal herbal formulas were not associated with an increased risk of cardiotoxicity in hERG-HEK 293 recombinant cells.

keywords
Medicinal herbal formulas, Korea traditional medicine, cardiac safety, cardiotoxicity, hERG potassium channel


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