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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

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증미오비탕이 Monosodium Iodoacetate 유발 관절연골손상에 미치는 영향

Effects of Jeungmiobi-tang on the Articular Cartilage Injuries Induced by Monosodium Iodoacetate in Rats

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2020, v.41 no.3, pp.138-151
현재철 (세명대학교 한의과대학 한방재활의학과교실)
정수현 (세명대학교 한의과대학 한방재활의학과교실)
현재철, & 정수현. (2020). 증미오비탕이 Monosodium Iodoacetate 유발 관절연골손상에 미치는 영향. 대한한의학회지, 41(3), 138-151.
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Abstract

Objectives: This study was carried out to investigate the protective effects of Jeungmiobi-tang on the articular cartilage injuries induced by monosodium iodoacetate in rats. Methods: Twenty four rats were divided into three groups. Rats of normal group (n=8) were injected with 0.1 ml physiological saline into both knee joint cavities. In the rats of control group (n=8) and Jeungmiobi-tang group (n=8), Arthritis was induced by injecting with 0.1 ml monosodium iodoacetate (5 mg/ml) into both knee joint cavities. After the experiment, Gross and histopathological examinations on the knee joint were performed. The content of proteoglycan in articular cartilage and TNF-α and IL-1β in synovial fluid were also analyzed. Results: Grossly, Injuries to the articular cartilage surface was observed weak in the Jeungmiobi-tang group compared to the control group. Proteoglycan content in the articular cartilage was significantly higher in the Jeungmiobi-tang group than in the control group. The chondrocyte score was significantly lower in the Jeungmiobi-tang group than in the control group. Conclusion: According to these results, that Jeungmiobi-tang has protective effects on the articular cartilage injuries induced by monosodium iodoacetate in rats.

keywords
Jeungmiobi-tang, Monosodium iodoacetate, Articular cartilage injury, Proteoglycan. Osteoarthritis


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