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  • P-ISSN 1010-0695
  • E-ISSN 2288-3339

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LPS유도 염증 동물모델에서 오적산의 항염증 효과

Anti-inflammatory Effects of Ojeok-san in LPS-induced Inflammatory Rat Model

대한한의학회지 / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2021, v.42 no.2, pp.21-30
김주희 (상지대학교 한의과대학 침구의학교실)
이동혁 (상지대학교 한의과대학 한의기초과학교실)
김지혜 (한국한의약진흥원)
정성은 (한국한의약진흥원)
함성호 (한국한의약진흥원)
양웅모 (경희대학교 한의과대학 융합한의학교실)
권보인 (상지대학교 한의과대학 병리학교실)
김주희, 이동혁, 김지혜, 정성은, 함성호, 양웅모, & 권보인. (2021). LPS유도 염증 동물모델에서 오적산의 항염증 효과. 대한한의학회지, 42(2), 21-30.
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Abstract

Objectives: The aim of this study is to investigate the anti-inflammatory effects of Ojeok-san and compare the therapeutic effects according to its formation. Methods: We evaluated the anti-inflammatory effects of Ojeok-san using lipopolysaccharide (LPS) induced inflammatory animal model. Male SD rats were administered intra-orally with two different formulation types of Ojeok-san according to prescribed dosage. One hour later, to induce inflammatory responses, subsequent intra-peritoneal injection of LPS was conducted. After 5 hours later, serum TNF-α, IL-1β, IL-6 and PGE2 levels were measured by ELISA to assess the alteration of pro-inflammatory markers. Results: In our experiment, regardless of its formation, administration of Ojeok-san decreased TNF-α, IL-1β, IL-6 and PGE2 level in serum. Furthermore, LPS-induced toxicity of liver and kidney was not detected by Ojeok-san administration. Conclusions: The anti-inflammatory effect of Ojeok-san was shown in LPS-induced inflammatory model by decreasing pro-inflammatory markers, and there would be no significant difference in therapeutic effect between two formulation types of Ojeok-san.

keywords
Ojeok-san, lipopolysaccharide(LPS)-induced model, anti-inflammatory effect, pro-inflammatory markers


참고문헌

1

1. No YB. A Literature Study on the Use of Ojeoksan. Journal of Herbal Formula Science. 1990;1(1):72-86.

2

2. Yun JY, Yun YG. A Prescriptional Study of Ojeoksan on Clinical Application. Journal of Herbal Formula Science. 2012;20(2):153-64.

3

3. Kim JD, Seo IB, Lee DN, Kim HJ. Effects of Ojeok-san on the Maturation of Follicles and NGF Expression in Rats with Estradiol Valerate-induced Polycystic Ovaries. Journal of Korean Obstetrics and Gynecology. 2011;24(1):27-41.

4

4. Kim JH, Soh KS, Jeong CG, Kim KH. Effects of Ojuck-san on Hyperlipidemia in Rats. Society of Preventive Korean Medicine. 2004;8(2):185-202.

5

5. Moon YH, Park YJ. Studies on the Anti-inflammatory and Analgesic Activities of Ohjuksan. Korean Journal of Pharmacognosy. 1994;25(3):258-63.

6

6. Lee MJ, Hwang DS, Lee JM, Jang JB, Lee KS, Lee CH. Activation of Immune System &Antimetastatic Effects of Ojeok-san by Oral Administration. Journal of Korean Obstetrics and Gynecology. 2014;27(2):34-45.

7

7. Shin KM, Jang MG, Kim EJ, Kim SW, Lee JD, Kim KS, et al. The Use of Ojeok-san in Low Back Pain Patients: Results of a Telephone Survey. 2010;27(2):71-8.

8

8. Yoo SR, Jeong SJ, Kim YJ, Lim HS, Jin SE, Jeon WY, et al. Effects of water and ethanol extracts from Ojeok-san on inflammation and its related disease. Korean J. Orient. Int. Med. 2012;33(4):418-28

9

9. Sun Y, Shang D. Inhibitory Effects of Antimicrobial Peptides on Lipopolysaccharide-Induced Inflammation., Mediators Inflamm., 2015;2015:167572.

10

10. Jiang Y, Wang MH. Ethanol extract of Synurus deltoides (Aiton) Nakai suppresses in vitro LPS-induced cytokine production in RAW 264.7 macrophages and in vivo acute inflammatory symptoms., Nutr Res Pract., 2014 Feb;8(1):11-9.

11

11. Luo YH, Yan J, Mao YF. Helicobacter pylori lipopolysaccharide: biological activities in vitro and in vivo, pathological correlation to human chronic gastritis and peptic ulcer., World J Gastroenterol., 2004 Jul 15;10(14):2055-9.

12

12. Neff SB, Z'graggen BR, Neff TA, Jamnicki -Abegg M, Suter D, Schimmer RC, et al. Inflammatory response of tracheobronchial epithelial cells to endotoxin., Am J Physiol Lung Cell Mol Physiol., 2006 Jan;290(1):L86-96. Epub 2005 Aug 12.

13

13. Nader ND, Asgeri M, Davari-Farid S, Pourafkari L, Ahmadpour F, Porhomayon J, et al. The Effect of Lipopolysaccharide on Ischemic-Reperfusion Injury of Heart: A Double Hit Model of Myocardial Ischemia and Endotoxemia., J Cardiovasc Thorac Res., 2015;7(3):81-6.

14

14. Gray T, Nettesheim P, Loftin C, Koo JS, Bonner J, Peddada S, et al. Interleukin-1beta -induced mucin production in human airway epithelium is mediated by cyclooxygenase-2, prostaglandin E2 receptors, and cyclic AMP -protein kinase A signaling., Mol Pharmacol., 2004 Aug;66(2):337-46.

15

15. Park MH, Yoon DY, Ban JO, Kim DH, Lee DH, Song S, et al. Decreased severity of collagen antibody and lipopolysaccharide -induced arthritis in human IL-32β overexpressed transgenic mice., Oncotarget. 2015 Nov 17;6(36):38566-77.

16

16. Ye JH, Liu MH, Zhang XL, He JY. Chemical Profiles and Protective Effect of Hedyotis diffusa Willd in Lipopolysaccharide-Induced Renal Inflammation Mice., Int J Mol Sci., 2015 Nov 13;16(11):27252-69.

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