- P-ISSN 1010-0695
- E-ISSN 2288-3339
- Apply for Authority
- P-ISSN1010-0695
- E-ISSN2288-3339
Article Detail
Home > Article Detail
Regulation of Gastric Acid Secretion of Liriope platyphylla Extract in Gastroesophageal Reflux Disease
Journal of Korean Medicine / Journal of Korean Medicine, (P)1010-0695; (E)2288-3339
2021, v.42 no.4, pp.160-173
&
(2021). Regulation of Gastric Acid Secretion of Liriope platyphylla Extract in Gastroesophageal Reflux Disease. Journal of Korean Medicine, 42(4), 160-173.
- Downloaded
- Viewed
Abstract
Objectives: The purpose of this study was to confirm the effects of Liriope platyphylla extract on relieving Gastroesophageal reflux disease (GERD) through regulation of acid secretion. Methods: 8-week-old ICR mice were divided into untreated control group (Ctrl), GERD elecitation group (GERDE), Omeprazole administrate group before GERD elicitation (OMA), and Liriope platyphylla extract administrate group before GERD elicitation (LPA). After inducing GERD, gross observation and histological examination were performed and ATP6V1B1 (ATPase H+ Transporting V1 Subunit B1), GRPR (Gastrin-releasing peptide receptor), COX-1 (Cyclooxygenase 1), 8-OHdG (8-hydroxy-2’-deoxyguanosine), Cathelicidin, p-JNK (phospho c-Jun N-terminal kinase) were observed to confirm the damage defense effect of the esophageal mucosa, acid secretion regulation, antioxidant, anti-inflammatory, mucosal protection, and apoptosis regulation Results: OMA and LPA showed lower levels of damage compared to GERDE in gross observation and histological examination. ATP6V1B1, GRPR, and 8-OHdG showed lower positive reactions in OMA and LPA than in GERDE. COX-1 were less positive in GERDE and OMA than in Ctrl, but showed higher secretion in LPA than in Ctrl. Cathelicidin showed a decreased positive reaction in GERDE, OMA and LPA compared to Ctrl, but the decrease in positive reaction was smaller in OMA and LPA compared to GERDE. p-JNK showed increased positive reaction in GERDE, OMA and LPA than in Ctrl, but the increase in the positive reaction was smaller in the OMA and LPA compared to GERDE. Conclusions: The effects of Liriope platyphylla extract on esophageal mucosal damage protection, acid secretion regulation, antioxidant, anti-inflammatory, mucosal protection and apoptosis regulation were confirmed.
- keywords
- Liriope platyphylla, Gastroesophageal reflux disease, acid secretion regulation, Cathelicidin, p-JNK
Reference
1
1. Jung, H. K., Hong, S. J., Jo, Y. J., Jeon, S. W., Cho, Y. K., Lee, K. J., et al. (2012). Updated guidelines 2012 for gastroesophageal reflux disease. Korean J Gastroenterol, 60(4), 195-218. https://doi.org/10.4166/kjg.2012.60.4.195
2
2. Fauci, A. S., Braunwald, E., Kasper, D. L., Hauser, S. L., Longo, D. L., Jameson, J. L., et al (2010). Harrison’s principles of internal medicine (17th ed.). MIP. https://doi.org/10. 1111/j.1445-5994.2008.01837.x
3
3. Maton, P. N. (1991). Omeprazole. N Engl J Med, 324(14), 965-75. https://doi.org/10.1056/NEJM199104043241406
4
4. Cheungpasitporn, W., Thongprayoon, C., Kittanamongkolchai, W., Srivali, N., Edmonds, P. J., Ungprasert, P., et al. (2015). Proton pump inhibitors linked to hypomagnesemia:A systematic review and meta-analysis of observational studies. Ren Fail, 37(7), 1237–41. https://doi.org/10.3109/0886022X.2015.1057800
5
5. Park, H. J., Park, S. H., Shim, K. N., Kim, Y. S., Kim, H. Y., Han, J. P., et al. (2016). The prevalence and clinical features of non-responsive gastroesophageal reflux disease to practical proton pump inhibitor dose in Korea: A multicenter study. Korean J Gastroenterol, 68(1), 16-22. https://doi.org/10. 4166/kjg.2016.68.1.16
6
6. Makunts, T., Alpatty, S., Lee, K. C., Atayee, R. S., & Abagyan, R. (2019). Proton-pump inhibitor use is associated with a broad spectrum of neurological adverse events including impaired hearing, vision, and memory. Sci Rep, 9(1), 17280. https://doi.org/10.1038/s41598-019-53622-3
7
7. Kim, D. H., Lee, J. E., You, S. H., Lee, H. A., Park, J. H., Jung, J. H., et al. Proton pump inhibitor use and risk of osteoporotic fracture in Korean adults with peptic ulcer disease and gastroesophageal reflux disease. Seoul: National Evidence-based Healthcare Collaborating Agency. 2017: 67-70.
8
8. Roh, S. S., Choi, H. J., Kim, D. H., & Seo, Y. B. (2008). Studies of anti-inflammation of Liriopis Tuber to autoimmunune diabetes in NOD mice. JPPKM, 22(4), 766-70.
9
9. Lee, E. S., Yang, S. Y., Kim, M. H., NamGung, & U., Park, Y. C. (2011). Effects of root of Liriope Spicata on LPS-induced Lung Injury. JPPKM, 25(4), 641-9.
10
10. Im, J. G., Kang, M. S., Park, I. K., & Kim, S. D. (2005). Dietary effect of Liriopis Tuber water extracts on the level of blood glucose and serum cholesterol in streptozotocin-induced diabetic rat. J East Asian Soc Dietary Life, 15(1), 20-8.
11
11. Lee, I. J., & An, J. Y. (2003). Hepatoprotective effects of water extract of Liriopis Tuber on carbon tetrachloride-induced hepatotoxicity in rats. Kor J Pharmacogn, 34(2), 166-71.
12
12. Lee, I. J., Baek, N. I., Cho, S. J., Bang, M. H., Kim, M. S., Park, C. G., et al. (1998). Cytotoxicity of steroid-saponins from the tuber of Liriope platyphylla W. T. Kor J Soc Agric Chem Biotechnol, 41(5), 390-4.
13
13. Jang, M. W., & Lim, S. W. (2013). Experimental study for effect of Banhasasim-tang on mice with reflux esophagitis. Korean J Orient Int Med, 34(4), 362-3.
14
14. Lee, S. K., & Lim, S. W. (2016). The administration of Jeungmiyijin-tang to rats with induced gastro reflux esophagitis. J Int Korean Med, 37(6), 1030-41. https://doi.org/10.22246/jikm.2016.37.6.103
15
15. Lee, S. T., & Kwak, M. A. (2013). Effects of individual herbal components of Yijin-tang-gamibang in the rat reflux esophagitis. Korean J Orient Int Med, 34(2), 165-77.
16
16. Shin, M. K., Kim, E. S., Kim, T. R., Lim, H. C., & Lee, Y. S. (2016). Effects of Jwa kum-whan on reflux esophagitis in rats. J Int Korean Med, 37(3), 495-507.
17
17. Kim, S. H., Roh, S. S., Lee, J. A., Shin, M. R., Lee, A. R., Koo, J. S., et al. (2019). Improving effects on rats with chronic acid reflux esophagitis treated of Coptidis Rhizoma extract. Kor J Herbol, 34(1), 117-24. https://doi.org/10.6116/kjh.2019.34.1.117
18
18. Lee, J. Y., Seo, B. I., & Roh, S. S. (2016). Improving effect of Artemisiae Capillaris herba extract in reflux esophagitis rats. Kor J Herbol, 31(6), 37-44. https://doi.org/10.6116/kjh.2016.31.6.37
19
19. Lee, J. A., Park, H. J., Kim, S. H., Kim, M. J., Kim, K. J., Shin, M. R., et al. (2019). Evaluation of Evodiae Fructus extract on the chronic acid reflux esophagitis in rats. Kor J Herbol, 34(2), 15-23. https://doi.org/10.15616/BSL.2021.27.2.77
20
20. Kim, D. J., & Roh, S. S. (2012). Effect on acute reflux esophagitis by Evodiae Fructus Aquous extract. Kor J Herbol, 27(1), 51-8. https://doi.org/10.6116/kjh.2012.27.1.51
21
21. Kwon, O. J., Lee, A. R., & Roh, S. S. (2016). Improving effects on rats with reflux esophagitis treated with combined extract of young persimmon fruit and Citrus peel. Kor J Herbol, 31(1), 25-31. https://doi.org/10.6116/kjh.2016.31.1.25
22
22. Shin, M. H., Kim, E. S., & Lee, Y. S. (2016). Suppressive effects of Ulmi Pumilae Cortex extracts on the reflux esophagitis in rat. JPPKM, 30(4), 257-65. https://doi.org/10. 15188/kjopp.2016.08.30.4.257
23
23. Shapiro, M., Green, C., Bautista, J. M., Dekel, R., Risner-Adler, S., Whitacre, R., et al. (2007). Assessment of dietary nutrients that influence perception of intra-oesophageal acid reflux events in patients with gastro -oesophageal reflux disease. Aliment Pharmacol Ther, 25(1), 93-101. https://doi.org/10.1111/j.1365-2036.2006.03170.x
24
24. Nakamura, K., Ozawa, Y., Furuta, Y., &Miyazaki, H. (1982). Effects of sodiumpolyacrylate (PANa) on acute esophagitis by gastric juice in rats. Jpn J Pharmacol, 32(3), 445-56. https://doi.org/10.1254/jjp.32.445
25
25. Stover, E. H., Borthwick, K. J., Bavalia, C., Eady, N., Fritz, D. M., Rungroj, N., et al. (2002). Novel ATP6V1B1 and ATP6V0A4mutations in autosomal recessive distal renal tubular acidosis with new evidence for hearing loss. J Med Genet, 39(11), 796-803. https://doi.org/10.1136/jmg.39.11.796
26
26. Finberg, K. E., Wagner, C. A., Bailey, M. A., Păunescu, T. G., Breton, S., Brown, D., et al. (2005). The B1-subunit of the ATPase is required for maximal urinary acidification. PNAS, 102(38), 13616-21. https://doi.org/10.1073/pnas.0506769102
27
27. Czepielewski, R. S., Porto, B. N., Rizzo, L. B., Roesler, R., Abujamra, A. L., Pinto, L. G., et al. (2012). Gastrin-releasing peptide receptor (GRPR) mediates chemotaxis in neutrophils. PNAS, 109(2), 547-52. https://doi.org/10.1073/pnas.1110996109.
28
28. Petronilho, F., Danielski, L. G., Roesler, R., Schwartsmann, G., & Dal-Pizzol, F. (2013). Gastrin-releasing peptide as a molecular target for inflammatory diseases: an update. Inflamm Allergy Drug Targets, 12(3), 172-7. https://doi.org/10.2174/1871528111312030003
29
29. Laine, L., Takeuchi, K., & Tarnawski, A. (2008). Gastric mucosal defense and cytoprotection:bench to bedside. Gastroenterology, 135(1), 41–60. https://doi.org/10.1053/j.gastro.2008.05. 030
30
30. Cryer, B., & Dubois, A. (1998). The advent of highly selective inhibitors of cyclooxygenase-a review. Prostaglandins Other Lipid Mediat, 56(5-6), 341-61. https://doi.org/10.1016/s0090-6980(98)00064-1
31
31. Zhou, X., Zhuang, Z., Wang, W., He, L., Wu, H., Cao, Y., et al. (2016). OGG1 is essential in oxidative stress induced DNA demethylation. Cell Signal, 28(9), 1163-71. https://doi.org/10.1016/j.cellsig.2016.05.021
32
32. Valavanidis, A., Vlachogianni, T., & Fiotakis, C. (2009). 8-hydroxy-2' -deoxyguanosine (8-OHdG): a critical biomarker of oxidative stress and carcinogenesis. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev, 27(2), 120-39. https://doi.org/10.1080/10590500902885684
33
33. Sorenseon, O., Cowland, J. B., Askaa, J., &Borregaard, N. (1997). An ELISA for hCAP-18, the cathelicidin present in human neutrophils and plasma. J Immunol Methods, 206(1-2), 53-9. https://doi.org/10.1016/S0022-1759(97)00084-7
34
34. Hase, K., Eckmann, L., Leopard, J. D., Varki, N., & Kagnoff, M. F. (2002). Cell differentiation is a key determinant of cathelicidin LL-37/human cationic antimicrobial protein 18 expression by human colon epithelium. Infect Immun, 70(2), 953-63. https://doi.org/10.1128/IAI.70.2.953-963.2002
35
35. Ip, Y. T., & Davis, R. J. (1998). Signal transduction by the c-Jun N-terminal kinase (JNK) — from inflammation to development. Curr Opin Cell Biol, 10(2), 205-19. https://doi.org/10.1016/s0955-0674(98)80143-9
36
36. Choi, B. H., Hur, E. M., Lee, J. H., Jun, D. J., & Kim, K. T. (2005). Protein kinase C delta-mediated proteasomal degradation of MAP kinase phosphatase-1 contributes to glutamate-induced neuronal cell death. J. Cell Sci, 119(7), 1329-40. https://doi.org/10. 1242/jcs.02837
37
37. Oh, H. L., Seok, J. Y., Kwon, C. H., Kang, S. K., & Kim, Y. K. (2006). Role of MAPK in ceramide-induced cell death in primary cultured astrocytes from mouse embryonic brain. NeuroToxicology, 27(1), 31-8. https://doi.org/10.1016/j.neuro.2005.05.008
- Downloaded
- Viewed
- 0KCI Citations
- 0WOS Citations
Other articles from this issue
- A pilot study of Korean Medical Examination
- Anti-inflammatory Effects in LPS-treated RAW 264.7 Cells and the Influences on Drug Metabolizing Enzyme Activities by the Traditional Herbal Formulas, Yongdamsagan-Tang and Paljung-san
- Assessment of genotoxicity of Ssanghwa-tang, an herbal formula, by using bacterial reverse mutation, chromosome aberration, and in vivo micronucleus tests
- A survey on the impact of a pharmacovigilance practice training course for future doctors of Korean medicine on their knowledge, attitudes, and perception
- Integrated Rehabilitation for Children with Cerebral palsy: A Prospective Observational Study
- The effectiveness and safety of cupping therapy for stroke survivors: A systematic review and meta-analysis of randomized controlled trials
- The Association between Facial Morphology and Cold Pattern
- Selection of Effective Herbal Medicines for Parkinson’s Disease Based on the Text Mining of the Classical Korean Medical Literature Donguibogam
- A Comparative Analysis on Korean Medical and Western Medical Service Usage Tendency of Rotator Cuff Surgery Patients - Using HIRA’s Patients Sample Data
- Regulation of Gastric Acid Secretion of Liriope platyphylla Extract in Gastroesophageal Reflux Disease
- Effects of LI11 Acupuncture on CO2 reactivity in the anterior and middle cerebral arteries during hyperventilation-induced hypocapnia in normal subjects: A before and after study
- Development of Mission and Vision of College of Korean Medicine Using the Delphi Techniques and Big-Data Analysis
- Study on the Anthropometric and Body Composition Indices for Prediction of Cold and Heat Pattern
- Effect of Reducing Inflammation of Coptis chinensis Extract -Ceramide Complex through ECS Control in Atopic Dermatitis
- A Narrative Review of Clinical researches of Acupuncture treatment for Depression using Neuroimaging method: Focusing on SCI papers
- A Systematic Review of Herbal Medicine in the Treatment of Cirrhotic Ascites
- Treatment of Recalcitrant Plantar Wart Unresponsive to Cryotherapy with Acupuncture and Moxibustion:A Case Report
- more
Recommanded Articles
This website recommended the use the Chrome browser for journal website.