Abstract

Purpose: This study analyzes the clinical research findings of Gyejibokryeonghwan (GBH), an herbal formula for treating gynecological diseases in 『Jinguiyaolue』, and aims to verify the clinical evidence regarding its efficacy and safety. Methods: Clinical reports on treating gynecological diseases with GBH were collected from RISS, NAVER, KISS, OASIS, PUBMED, and Science Direct. The compiled literature was assessed by disease and research method, and the primary findings were summarized and considered. Results: Overall, 37 reports were classified by disease: five on uterine leiomyoma; two on polycystic ovary syndrome; two on chronic pelvic peritonitis or unspecified pelvic inflammatory disease; four on endometriosis; nine on primary, secondary, and unexplained dysmenorrhea; 13 on menopause and menopausal status; one on female infertility; and one undetermined. GBH’s therapeutic effect on these diseases was confirmed, and no serious side effects were reported. Furthermore, when GBH is administered with modern medicines for existing gynecological diseases, it enhances treatment efficacy and reduces side effects. Conclusion: GBH is a safe and effective herbal medicine for treating the aforementioned gynecological diseases with minimal side effects.