The Orff method is one of the most popular music teaching systems in the world. It was first created by the famous educator and child musician Carl Orff and has since been inherited and developed by many experts. With the reform and opening up of China and the introduction of Orff’s music teaching method, the theoretical and practical aspects of music education in China have quietly changed. In this study, the effects of the Orff method and the traditional method on the interpersonal skills, self-esteem and well-being of music education undergraduates at GG University in China were investigated using an experimental control method. The results of the study showed that under both teaching methods, the interpersonal skills, self-esteem and happiness of the music education undergraduates in the experimental group were significantly higher than those in the control group after 12 weeks of the Orff teaching method intervention (p<0.05), therefore, it was concluded that the Orff teaching method could influence emotion regulation, strengthen positive emotions and regulate individuals’ negative emotions, enhance interpersonal skills, self-esteem and happiness, guiding the university students to face future development and challenges with confidence, maintaining their mental health, and promoting the better development of education. In the past, the study of the Orff music teaching method was only limited to the musical initiation of children from kindergarten to primary school. However, as more and more people around the world study and practice the Orff education system, it has been extended to secondary schools, universities and colleges. It has now been extended to a wide range of areas such as secondary schools, music classes in colleges and universities, music therapy and health for the elderly, with people of all ages enjoying the benefits of Orff music education. This study demonstrates that the Orff method can influence emotion regulation, strengthen positive emotions and regulate negative emotions of individuals, and enhance interpersonal skills, self-esteem and well-being.