- P-ISSN2287-1608
- E-ISSN2287-1616
- KCI
ISSN : 2287-1608
R&D Sustainability of Biotech Start-ups in Financial Risk
Abstract
This paper’s objective is to draw a decision guideline to continue research and development (R&D) investments in biotech start-ups facing the “Valley of Death” syndrome ¬- a long negative profit period during a financial crisis. The data include financial indices as Net income, Revenues, Total stockholders’ equity, Cash & equivalents, and R&D expenses of 18 major biotech companies (nine in negative profit and nine positive, in FY2008) and 15 major pharmaceutical corporations as benchmarks both in FY2008 and in FY2016 derived from the US SEC Database, EDGAR. A first methodology dealing with real options analysis assumes Total stockholders’ equity as a growth option. And a second methodology, Bayesian Markov chain Monte Carlo (MCMC) analysis, is applied to test the probability relationship between the Total stockholders’ equity and the R&D expenses in these three groups. This study confirms that Total stockholders’ equity can play the role of a call option to support continuing R&D investments even in negative profits.
- keywords
- Biotech start-ups, valley-of-death, R&D sustainability, Bayesian MCMC, financial crisis
Reference
Aktekin, T., Dutta, D.K. and Sohl, J.E. (2017) Entrepreneurial firms and financial attractiveness for securing debt capital: a Bayesian analysis, Venture Capital, 20(1), 1-24.
Amram, M. and Kulatilaka, N. (2000) Strategy and shareholder value creation: the real options frontier, Journal of Applied Corporate Finance, 13(2), 15-28.
Audretsch, B. (1998) Agglomeration and the location of innovative activity, Oxford Review of Economic Policy, 14(2), 18-29.
Audretsch, D.B., Aldridge, T.T. and Sanders, M. (2011) Social capital building and new business formation: a case study in silicon valley, International Small Business Journal, 29(2), 152-169.
Auerswald, P.E. and Branscomb, L.M. (2003) Valleys of death and darwinian seas: financing the invention to innovation transition in the united states, Journal of Technology Transfer, 28(3-4), 227-239.
Binder, G. and Bashe, P. (2008) Science Lessons: What the Business of Biotech Taught Me about Management, Cambridge, MA: Harvard Business School Press.
Black, F. and Scholes, M. (1973) The pricing of options and corporate liabilities, Journal of Political Economy, 81(3), 637-659.
Block, F. (2008) Swimming against the current: the rise of a hidden developmental state in the united states, Politics and Society, 36(2), 169-206.
Bogdan, B. and Villiger, R. (2010) Valuation in Life Sciences: A Oractical Guide, Berlin: Springer.
Bowman, E.H. and Moskowitz, G.T. (2001) Real options analysis and strategic decision making, Organization Science, 12(6), 772-777.
Brindley, D. and Davie, N. (2009) Regenerative medicine through a crisis: social perception and the financial reality, Rejuvenation Research, 12(6), 455-461.
Castellaneta, F. and Gottschalg, O. (2014) Does ownership matter in private equity? the sources of variance in buyouts' performance, Strategic Management Journal, 37(2), 330-348.
Copeland, T.E. and Antikarov, V. (2001) Real Options, New York: Texere.
Dixit, A. and Pindyck, R.S. (1994) Investment Under Uncertainty, Princeton, NJ: Princeton University Press.
Etzkowitz, H. (2006) The new visible hand: an assisted linear model of science and innovation policy, Science and Public Policy, 33(5), 310-320.
Feldman, M.P. (2003) The locational dynamics of the US biotech industry: knowledge externalities and the anchor hypothesis, Industry and Innovation, 10(3), 311-328.
Finkbeiner, S. (2010) Bridging the valley of death of therapeutics for neurode-generation, Nature Medicine, 16, 1227-1232.
Garnsey, E.W., Galloway, S.C. and Mathisen, S.H. (2006) Flexibility and specialization in question; birth, growth and death rates of Cambridge new technology-based firms 1988-92, Entrepreneurship and Regional Development, 6(1), 81-107.
Hughes, S.S. (2011) Genentech: The Beginnings of Biotech (Synthesis), Chicago: University of Chicago Press.
Jägle, A.J. (1999) Shareholder value, real options, and innovation in technology-intensive companies, R&D Management, 29(3), 271-288.
Kester, W.C. (1984) Today’s options for tomorrow’s growth, Harvard Business Review, 62(2) March-April, 153-160.
Kruschke, J. (2014) Doing Bayesian Data Analysis: A Tutorial with R, JAGS, and Stan, 2nd ed., London: Academic Press.
McGrath, R.G. (1999) Falling forward: real options reasoning and entrepreneurial failure, Academy of Management Review, 24(1), 13-30.
Merton, R.C. (2007) Theory of rational option pricing, Bell Journal of Economics, 4(1), 141-183.
Moran, N. (2007) Public sector seeks to bridge 'valley of death', Nature Biotechnology, 25(3), 266.
Myers, S.C. (1977) Determinants of corporate borrowing, Journal of Financial Economics, 5(2), 147-176.
Ottoo, R.E. (1998) Valuation of internal growth opportunities: the case of a biotechnology company, Quarterly Review of Economics and Finance, 38(3), 615-633.
Perlitz, M., Peske, T. and Schrank, R. (1999) Real options valuation: the new frontier in R&D project evaluation? R&D Management, 29(3), 255-270.
Pisano, G.P. (2006) Science Business: The Promise, the Reality and the Future of Biotech, Cambridge, MA: Harvard Business School Press.
Teconomy Partners LLC, (2018) Strengthening Biopharmaceutical Innovation, PhRMA.
USA Securities and Exchange Commission (2017) EDGAR, Retrieved from https://www.sec.gov/edgar.shtml.
Vassolo, R.S., Anand, J. and Folta, T.B. (2004) Non-additivity in portfolios of exploration activities: a real options-based analysis of equity alliances in biotechnology, Strategic Management Journal, 25(11), 1045-1061.
Waluszewski, A. (2004) A competing or co-operating cluster or seven decades of combinatory resources? what's behind a prospering biotech valley?, Scandinavian Journal of Mangement, 20(1-2), 125-150.
Werth, B. (2014) The Antidote: Inside the World of New Pharma, New York: Simon & Schuster.
Zhong, H., Liu, C., Zhong, J. and Xiong, H. (2018) Which startup to invest in: a personalized portfolio strategy, Annals of Operations Research, 263(1-2), 339-360.
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