만성신부전 환자에서 혈액투석이 폐기능 및 기관지확장제에 대한 반응에 미치는 영향
Immediate Effect of Hemodialysis onPulmonary Function and Bronchodilator Response in Patientswith Chronic Renal Failure
이양덕 (을지대학교)
조용선 (을지대학교)
한민수 (을지대학교)
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Abstract
Background : We hypothesized that there was a relationship between body weight change and bronchodilator response (BDR) in patients with chronic renal failure (CRF) on hemodialysis (HD). Several mechanisms such as pulmonary edema due to water retention or increased permeability of alveolar capillary may play a important role in pulmonary function impairment and bronchial hyperresponsiveness in patients with CRF on HD. But, no studies have been published concerning BDR in patients with CRF on HD. This study was aimed to know the immediate effect of hemodialysis on pulmonary function and BDR in patients with CRF on HD.Methods : This study included 30 patients with CRF on HD. We collected data including age, sex, height, pretibial and pedal pitting edema, interdialysis weight gain, postdialysis weight loss , underlying diseases, duration of HD, FEV1, FVC, FEV1/FVC, and BDR before and after HD.Results : Interdialysis weight gain of the patients was 3.4 1.0 kg, and postdialysis weight loss was 3.2 0.7 kg. Before HD, FEV1, FVC, and FEV1/FVC of the patients were 89 22%, 86 19% of predicted, and 87 10 %. After bronchodilator inhalation, these parameters were changed to 95 22%, 90 19% of predicted, and 88 9% respectively. BDR was positive in 15 patients. After HD, FEV1, FVC, and FEV1/FVC of the patients were 100 23%, 94 18% of predicted, and 88 11%. After bronchodilator inhalation, these parameters were changed to 102 23%, 96 18% of predicted, and 89 8% respectively. BDR was positive in 9 patients.Conclusion : First, HD increases FEV1, FVC, and FEV1/FVC but little affects BDR. Second, there is no correlation between postdialysis weight loss and increases in FEV1, FVC, and FEV1/FVC after HD. Third, there is also no correlation not only between interdialysis weight gain and BDR before HD but between postdialysis weight loss and BDR after HD. (Tuberculosis and Respiratory Diseases 2004, 56:77-84)
- keywords
- Chronic renal failure, Hemodialysis, Bronchodilator response.
참고문헌
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