만성폐쇄성폐질환에서 ACE 유전자 다형성과 기관지 과민성의 연관성
Polymorphisms of Angiotensin-convertingEnzyme Gene Associated in Patients withCOPD with or without Bronchial Hyperresponsiveness
이양근 (전북대학교)
이흥범 (전북대학교)
박성주 (전북대학교)
이용철 (전북대학교)
최유진 (건양대학교)
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Abstract
Background : An insertion-deletion polymorphism of angiotensin converting enzyme (ACE) gene has been shown to be associated with enzyme activity levels of ACE. Reported results that have been mutually contradictory about asthmatic hypersensitiveness and occurrence according to ACE gene insertion (I)/deletion (D) polymorphism. Also, the involvement of the ACE genes as the genetic basis of bronchial asthma is currently controversy. We investigated whether there was any association between polymorphisms of the ACE genes and airway hyper-responsiveness in chronic obstructive pulmonary disease (COPD).Methods : A total of 100 patients with COPD were enrolled in this study. The ACE genotypes were determined in all subjects by polymerase chain reaction. Pulmonary function test including bronchodilator response (BDR), methacholine bronchial provocation test (MBPT) were done in those patients. Airway hyper-responsiveness include any findings of positive BDR or MBPT.Results : In COPD patients, the ACE genotype distribution did not differ significantly among groups of patients with severities of COPD, and with or without airway hyper-responsiveness.Conclusions : These results suggest that polymorphisms of the ACE gene may not be associated with airway hyper-responsiveness, development and severity of COPD. (Tuberc Respir Dis 2005; 58:25-30)
- keywords
- Angiotensins, Enzymes, Polymorphism, COPD
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