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Tuberculosis & Respiratory Diseases

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Vol.59 No.3
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M.tuberculosis Somatic Antigen Specific CD8+T cell Responses in BCG-Vaccinated Subjects

Tuberculosis & Respiratory Diseases / Tuberculosis & Respiratory Diseases,
2005, v.59 no.3, pp.272-278





& (2005). M.tuberculosis Somatic Antigen Specific CD8+T cell Responses in BCG-Vaccinated Subjects. Tuberculosis & Respiratory Diseases, 59(3), 272-278.
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Abstract

Background : The immune responses mediated by CD8+T cells are known to be significant in controlling M. tuberculosis infections. In order to determine the role of cytotoxic CD8+T cells in the protective immune mechanism in latently infected subjects, this study examined whether or not the cytotoxic immune responses of CD8+T cells specific to the M. tuberculosis somatic antigens are induced in BCG vaccinated healthy subjects. Methods : Cytotoxicity and IFN-γ elispot assays were used to investigate the activities of CD8+T cells specific for the thyA30-38 peptide epitope in circulating peripheral blood mononuclear cells (PBMC) from BCG-vaccinated HLA-A*0201 and A*0206 subjects. Results : The results indicate the cytotoxic and IFN-γ immune responses of CD8+T cells specific for thyA30-38 were induced in BCG vaccinated healthy subjects. Conclusion : The cytotoxic and IFN-γ responses by CD8+T cells specific for the M. tuberculosis somatic antigens are induced in BCG-vaccinated subjects, and appear to be involved in the protective immune mechanism in latently infected people against a M. tuberculosis infection. (Tuberc Respir Dis 2005; 59: 272-278)

keywords
CD8+T cells, cytotoxicity, M. tuberculosis somatic antigens, CD8+T cells, cytotoxicity, M. tuberculosis somatic antigens

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Tuberculosis & Respiratory Diseases

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