삼출성 흉수에서 기질 금속단백분해효소-1과 금속단백분해효소의 조직억제제-1
Matrix Metalloproteinase-1 and Tissue Inhibitor of Metalloproteinase-1 levels in Exudative Pleural Effusions
곽승민 (인하대학교)
이홍렬 (인하대학교)
남정현 (인하대학교)
이금호 (인하대학교)
윤병갑 (인하대학교)
류정선 (인하대학교)
- 다운로드 수
- 조회수
초록
배 경 : 흉수에서 기질 금속단백분해효소(MMP)와 금속단백분해효소 조직억제제(TIMP)는 감염과 면역질환의 병인에 중요한 역할을 한다. 저자들은 삼출성 흉수에서 MMP-1과 TIMP-1의 발현에 대한 측정을 하였다.방 법 : 결핵성 흉막염 33예, 악성흉수 17예, 심부전 또는 간경화 흉수환자 5예의 흉막천자액에서 세포분석, 생화학적 분석을 하였고, 효소면역측정방법으로 MMP-1과 TIMP-1(Biotrack™, Amersharm Pharmacia Biotech, Freiburg, FRG)를 측정하였다.
- keywords
- Matrix metalloproteinase, Pleural effusion, Tissue inhibitor of metalloproteinase, Matrix metalloproteinase, Pleural effusion, Tissue inhibitor of metalloproteinase
Abstract
Background : The balances of the proteinases and antiproteinases system have been implicated in the pathogenesis of various exudative pleural effusions. The aim of this study was to examine the matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) levels in exudative pleural effusions. Methods : The study included 33 tuberculous effusions, 17 malignant, and 5 transudates. The pleural levels of MMP-1 and TIMP-1 were determined using a commercially available ELISA assay. Results : The group of tuberculous effusions showed higher pleural MMP-1 levels than the malignant and transudates. The pleural TIMP-1 levels of the tuberculous and malignant effusions were higher than the transudates. Conclusion : Elevated pleural MMP-1 and TIMP-1 levels were found in tuberculous effusions. (Tuberc Respir Dis 2005; 59: 517-521)
- keywords
- Matrix metalloproteinase, Pleural effusion, Tissue inhibitor of metalloproteinase, Matrix metalloproteinase, Pleural effusion, Tissue inhibitor of metalloproteinase
참고문헌
Antony VB, (jimmunol1993) Recruitment of inflammatory cells to the pleural space IL-8 and monocyte chemotactic peptide-1 in human pleural fluids,
Philip-Joet F, (1995) Fibrolytic and inflammatory processes in pleural effusion,
Hurewitz AN, (1992) Human pleural effusions are rich in matrix metalloproteases,
Birkedal-Hansen H, (1993) Matrix metalloproteinase:a review,
Stetler-Stevenson WG, (1996) Dynamics of matrix turnover during pathologic remodeling of the extracellular matrix,
O’Connor CM, (1994) Matrix metalloproteases and lung disease,
Eickelberg O, (1997) MMP and TIMP expression in pleural effusions of different origin,
Light RW, (1972) Pleural effusion:the diagnostic separation of transudates and exudates,
Ocana I, (1983) Adenosine deaminase in pleural fluid:test for diagnosis of tuberculous pleural effusion,
Murphy G, (1992) The matrix metalloproteinase and their inhibitors,
Segura-Valdez L, (2000) Upregulation of gelatinases A and B,collagenase 1 and 2,and increased parenchymal cell death in COPD,
Hoheisel G, (2001) Occurance of matrix metalloproteinases and tissue inhibitors of metalloproteinases in tuberculous pleuritis,
Chang JC, (1996) Effect of Mycobacterium tuberculosis and its components on macrophages and the release of matrix metalloproteinases,
Iglesias D, (2005) Metalloproteinases and tissue inhibitors of metalloproteinases in exudative pleural effusions,
Odeh M, (2002) Correlation between polymorphonuclear leukocyte counts and levels of tumor necrosis factor-α in pleural fluid of patients with parapneumonic effusion,
- 다운로드 수
- 조회수
- 0KCI 피인용수
- 0WOS 피인용수