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Tuberculosis & Respiratory Diseases

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Vol.60 No.5
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Clinical implication of Dendritic Cell Infiltration in Cervical Tuberculous Lymphadenitis

Tuberculosis & Respiratory Diseases / Tuberculosis & Respiratory Diseases,
2006, v.60 no.5, pp.523-531











& (2006). Clinical implication of Dendritic Cell Infiltration in Cervical Tuberculous Lymphadenitis. Tuberculosis & Respiratory Diseases, 60(5), 523-531.
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Abstract

Background : Cervical tuberculous lymphadenopathy is a very common disease with a similar incidence to pulmonary tuberculosis. Dendritic cells play a role of initial antigen presentation of this illness. Nevertheless, the precise role of these antigen-presenting cells according to the clinical features in unclear. The aim of this study was to determine the clinical implication of dendritic cell infiltration in the cervical lymph nodes.Methods : A review of the clinical characteristics was carried out retrospectively based on the clinical records and radiography. Immunohistochemical staining was performed on the available histology specimens of 72 cases using the S-100b polyclonal antibody for dendritic cells. The number of dendritic cells with tuberculous granuloma were determined. A X2 test, unpaired T test and multiple logistic regression analysis were performed.Results : Thirty percent of subjects had previous or concurrent pulmonary TB. Twenty one percent of cases showed a positive reaction on the AFB stain. Within a granuloma, the number of infiltrated dendritic cells was 113.0±7.0. The incidence of fever and cough decreased with increasing infiltration of dendritic cells Multivariate regression analysis showed that the infiltration of dendritic cells could significantly contribute to fever.Conclusion : Overall, dendritic cells can control a Mycobacterium tuberculosis infection and modulate the immune response, as well as resolve the clinical manifestations of TB lymphadenopathy.(Tuberc Respir Dis 2006; 60: 523-531)

keywords
Tuberculosis, Lymph Node, S-100b, Dendritic Cells.

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