결핵성 경부 림프절염에서 수지상돌기세포의 침윤과 임상양상의 연관성
Clinical implication of Dendritic Cell Infiltration in Cervical Tuberculous Lymphadenitis
이화연 (중앙대학교)
신종욱 (중앙대학교)
김재열 (중앙대학교)
박인원 (중앙대학교)
최병휘 (중앙대학교)
김미경 (중앙대학교)
최재철 (중앙대학교)
이영우 (중앙의대)
유승민 (성균관대학교)
임성용 (중앙의대)
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Abstract
Background : Cervical tuberculous lymphadenopathy is a very common disease with a similar incidence to pulmonary tuberculosis. Dendritic cells play a role of initial antigen presentation of this illness. Nevertheless, the precise role of these antigen-presenting cells according to the clinical features in unclear. The aim of this study was to determine the clinical implication of dendritic cell infiltration in the cervical lymph nodes.Methods : A review of the clinical characteristics was carried out retrospectively based on the clinical records and radiography. Immunohistochemical staining was performed on the available histology specimens of 72 cases using the S-100b polyclonal antibody for dendritic cells. The number of dendritic cells with tuberculous granuloma were determined. A X2 test, unpaired T test and multiple logistic regression analysis were performed.Results : Thirty percent of subjects had previous or concurrent pulmonary TB. Twenty one percent of cases showed a positive reaction on the AFB stain. Within a granuloma, the number of infiltrated dendritic cells was 113.0±7.0. The incidence of fever and cough decreased with increasing infiltration of dendritic cells Multivariate regression analysis showed that the infiltration of dendritic cells could significantly contribute to fever.Conclusion : Overall, dendritic cells can control a Mycobacterium tuberculosis infection and modulate the immune response, as well as resolve the clinical manifestations of TB lymphadenopathy.(Tuberc Respir Dis 2006; 60: 523-531)
- keywords
- Tuberculosis, Lymph Node, S-100b, Dendritic Cells.
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