사람면역결핍바이러스 감염에 동반된 미만성 침윤성 림프구 증가 증후군 1예
A Case of Diffuse Infiltrative Lymphocytosis Syndrome Associated with Human Immunodeficiency Virus Infection
이혁표 (인제대학교)
염호기 (인제대학교)
이성순 (인제대학교)
강윤경 (인제대학교)
김주인 (인제대학교)
최수전 (인제대학교)
이영민 (인제대학교)
박원우 (인제의대)
이현경 (인제의대)
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초록
사람면역결핍바이러스(HIV) 감염에 동반되는 미만성 침윤성 림프구 증가 증후군(diffuse infiltrative lymphocytosis syndrome, DILS)은 순환 CD8+ T-세포의 증가와 침샘, 폐, 신장, 위장관 등에 조직 침윤이 특징인 질환이다. HIV 항체(효소 면역 측정법)가 양성이며, 양측 침샘 크기가 증가되거나 6개월 이상 구강건조증이 있으며, 침샘이나 눈물샘 또는 침범된 조직 검사에서 육아종이나 악성 종양의 증거 없이 림프구 침윤이 있으면 미만성 침윤성 림프구 증가 증후군으로 진단한다. HIV 감염에 동반된 미만성 침윤성 림프구 증가 증후군이 폐에 침범된 경우는 아직 우리나라에서 보고된 예는 없다. 저자들은 사람면역결핍바이러스(HIV)에 감염된 58세 남자에게 미만성 침윤성 림프구 증가 증후군이 폐에 침범된 1예를 개흉생검으로 진단하여 문헌 고찰과 함께 보고한다.
- keywords
- Diffuse infiltrative lymphocytosis syndrome, HIV, CD8+., Diffuse infiltrative lymphocytosis syndrome, HIV, CD8+.
Abstract
Diffuse infiltrative lymphocytosis syndrome is an autoimmune syndrome that is characterized by the oligoclonal expansion of CD8+ T-lymphocytes in response to human immunodeficiency virus (HIV) antigens. The clinical manifestations include bilateral enlargement of the parotid glands, lymphocytic interstitial pneumonitis, lymphocytic hepatitis, neurological involvement and systemic lymphadenopathies. In addition to a positive HIV test, the diagnostic histopathological findings are CD8+ T-lymphocytic infiltrations in the lymphnodes, liver, lung, muscle and the salivary or lacrimal glands without granulomatous or neoplastic involvement. We report a case of pulmonary involvement of diffuse infiltrative lymphocytosis syndrome that was associated with a human immunodeficiency virus infection. (Tuberc Respir Dis 2006; 61: 289-293)
- keywords
- Diffuse infiltrative lymphocytosis syndrome, HIV, CD8+., Diffuse infiltrative lymphocytosis syndrome, HIV, CD8+.
참고문헌
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