폐경기 호르몬 대체요법 후 발생한 폐 색전증
Pulmonary Thromboembolism after Post-menopause Hormonal Replacement Therapy
염호기 (인제대학교)
이혁표 (인제대학교)
최수전 (인제대학교)
박종혁 (인제의대)
이현경 (인제의대)
이혜경 (인제의대)
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초록
폐경기 여성에서 호르몬 대체요법은 폐경기 증상의 경감, 골다공증에 의한 골절, 대장암의 위험도 감소 등의 효과가 인정되어 왔다. 현재도 많은 폐경기 여성에게 사용되어지고 있는 치료법이다. 그러나 그에 따른 부작용 또한 점차 밝혀지며 연구 되고 있다. 이러한 부작용 중 생명을 위협 할 수 있는 폐색전증은 호르몬요법을 사용할시 항상 각별한 주의를 요한다. 폐경기 호르몬대체요법이 필요할 경우 심부정맥혈전증과 폐색전증의 다른 위험인자나 환경적 요인 등을 가진 환자에게 그 사용에 있어 더욱 주위를 기울여야 한다. 또한 폐색전증의 가장 많은 증상인 호흡기 증상이 있을 경우 즉시 적절한 평가와 치료가 필요하다.
- keywords
- Postmenopause hormone replacement therapy(HRT), Pulmonary thromboembolism, Deep vein thrombosis., Postmenopause hormone replacement therapy(HRT), Pulmonary thromboembolism, Deep vein thrombosis.
Abstract
Hormonal replacement therapy (HRT) has been proven for treatment of postmenopausal symptoms such as hot flushes, night sweats and urologic symptoms. HRT became very popular in the 1990's, when there were several reports showing that it also helped with other menopausal complications such as osteoporosis and cardiovascular disease. Recent studies report that the incidence of breast cancer, endometrial cancer, cerebral infarction, coronary artery diseases, deep vein thrombosis and pulmonary thrombembolism could rise after HRT. Among these side effects of HRT, the risk of pulmonary thromboembolism increases 2 to 4 fold after HRT, but can vary with the use of different doses and preparations. Here, we summarize the risk factors and clinical courses for 5 patients who developed pulmonary thromboembolism after postmenopausal HRT. (Tuberc Respir Dis 2007; 63: 362-366)
- keywords
- Postmenopause hormone replacement therapy(HRT), Pulmonary thromboembolism, Deep vein thrombosis., Postmenopause hormone replacement therapy(HRT), Pulmonary thromboembolism, Deep vein thrombosis.
참고문헌
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