바로가기메뉴

본문 바로가기 주메뉴 바로가기

Fatal Tumor Lysis Syndrome During Chemotherapy in Small Cell Lung Cancer

Tuberculosis & Respiratory Diseases / Tuberculosis & Respiratory Diseases,
2008, v.64 no.3, pp.215-218








  • Downloaded
  • Viewed

Abstract

Tumor lysis syndrome is a life-threatening complication of anti-cancer therapy that typically occurs in patients with large, rapidly growing and treatment-sensitive tumors such as high-grade lymphomas and acute leukemias. However, its incidence in solid tumors has been known to be very low. Tumor lysis syndrome in solid tumors has a high mortality rate owing to the lack of prophylactic therapy to prevent this complication. We report a case of fatal tumor lysis syndrome developed during chemotherapy in extensive-stage small cell lung cancer, along with a brief review of the relevant literature considering the rarity of this manifestation in solid tumor.

keywords
Small cell lung cancer, Tumor lysis syndrome

Reference

1.

1. Hande KR, Garrow GC. Acute tumor lysis syndrome in patients with high- grade non-Hodgkin's lymphoma.Am J Med 1993;94:133-9.

2.

2. Arrambide K, Toto RD. Tumor lysis syndrome. Semin Nephrol 1993;13:273-80.

3.

3. Gemici C. Tumour lysis syndrome in solid tumours.Clin Oncol (R Coll Radiol) 2006;18:773-80.

4.

4. Baeksgaard L, Sorensen JB. Acute tumor lysis syndrome in solid tumors-a case report and review of the literature. Cancer Chemother Pharmacol 2003;51:187-92.

5.

5. Kallab AM, Jillella AP. Tumor lysis syndrome in small cell lung cancer. Med Oncol 2001;18:149-51.

6.

6. Hussein AM, Feun LG. Tumor lysis syndrome after induction chemotherapy in small-cell lung carcinoma.Am J Clin Oncol 1990;13:10-3.

7.

7. Beriwal S, Singh S, Garcia-Young JA. Tumor lysis syndrome in extensive-stage small-cell lung cancer. Am J Clin Oncol 2002;25:474-5.

8.

8. Davidson MB, Thakkar S, Hix JK, Bhandarkar ND,Wong A, Schreiber MJ. Pathophysiology, clinical consequences,and treatment of tumor lysis syndrome. Am J Med 2004;116:546-54.

9.

9. Kalemkerian GP, Darwish B, Varterasian ML. Tumor lysis syndrome in small cell carcinoma and other solid tumors. Am J Med 1997;103:363-7.

10.

10. Cairo MS, Bishop M. Tumor lysis syndrome: new therapeutic strategies and classification. Br J Haematol 2004;127:3-11.

Tuberculosis & Respiratory Diseases