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Tuberculosis & Respiratory Diseases

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Vol.65 No.4
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Isoniazid를 포함한 항결핵약제 투여 후 발생한 여성형 유방 증례 1예

A Case of Bilateral Gynecomastia Associated with Isoniazid

Tuberculosis & Respiratory Diseases / Tuberculosis & Respiratory Diseases,
2008, v.65 no.4, pp.308-312
허은영 (서울대학교)
정인아 (서울의대)
이재석 (서울의대 내과)
이창훈 (서울대학교)
정희순 (서울대학교)
김덕겸 (서울대학교)
허은영, 정인아, 이재석, 이창훈, 정희순, & 김덕겸. (2008). Isoniazid를 포함한 항결핵약제 투여 후 발생한 여성형 유방 증례 1예. Tuberculosis & Respiratory Diseases, 65(4), 308-312.
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초록

저자들은 폐결핵으로 진단받고 결핵 약제를 복용하던 환자에서 발생한 여성형 유방에 대하여 검사를 시행한 결과 Isoniazid를 포함한 항결핵약제를 복용 후 발생한 여성형 유방 사례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

keywords
Gynecomastia, Isoniazid

Abstract

Gynecomastia is a benign enlargement of the male breast attributable to proliferation of the ductal elements. Gynecomastia has been rarely reported as an adverse effect of isoniazid therapy. We report the case of a 35-year-old man who was prescribed with isoniazid, rifampicin, ethambutol and pyrazinamide to treat pulmonary and lymphatic tuberculosis. After five months of treatment, the patient complained of painful engorgement in the bilateral breasts and the presence of male gynecomastia was confirmed with a physical examination and radiographical methods. The serum level of estradiol was also increased. Common causes of male gynecomastia were excluded through history taking and the laboratory findings. The anti-TB drugs were changed to a second line regimen due to radiographical progression and the intolerance of the patient to gynecomastia. Gynecomastia was relieved very slowly and a tender subareolar palpable mass decreased in size and consistency over five-month period after stopping the probable causative drug, isoniazid. From a review of the literature, gynecomastia has been shown to be a side effect of treatment with first line anti-tuberculosis drugs, and especially with isoniazid. We report the rare case.

keywords
Gynecomastia, Isoniazid

참고문헌

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Tuberculosis & Respiratory Diseases

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