A Case of Papillary Adenocarcinoma Presenting with Multiple Cysts

A 23-year old woman was admitted to our hospital with hemoptysis. The chest X-ray showed reticulonodular opacity and multiple cysts throughout the entire lung field. The chest CT scan revealed numerous bilateral cysts with various sizes, some of them with thickened walls. An open lung wedge resection was performed. The resected specimen showed scattered small nodules, 0.3 to 0.6 cm in size. Microscopically, each nodule was composed of atypical glands with an occasional papillary architecture spreading to the alveolar septa, which were morphologically consistent with a papillary adenocarcinoma with a bronchioloalveolar carcinoma growth pattern. Immunochemically, the tumor cells were negative for the S-100 protein. The patient was diagnosed with an adenocarcinoma of the lung. A variety of diseases can produce or mimic multiple, thin-walled cysts in the lung. Lung cancer with multiple cysts is quite rare. Nevertheless, adenocarcinoma should be a diagnostic consideration. We report a case of a multiple cystic adenocarcinoma of the lung.

keywords: Lung Neoplasms, Adenocarcinoma, Cysts

참고문헌

1. Hansell DM, Bankier AA, MacMahon H, McLoud TC,Müller NL, Remy J. Fleischner society: glossary of terms for thoracic imaging. Radiology 2008;246:697-722.

2. Woodring JH, Fried AM. Significance of wall thickness in solitary cavities of the lung: a follow-up study. AJR Am J Roentgenol 1983;140:473-4.

3. Woodring JH. Unusual radiographic manifestations of lung cancer. Radiol Clin North Am 1990;28:599-618.

4. Chaudhuri MR. Primary pulmonary cavitating carcinomas.Thorax 1973;28:354-66.

5. Woodring JH, Stelling CB. Adenocarcinoma of the lung: a tumor with a changing pleomorphic character.Am J Roentgenol 1983;140:657-64.

6. Hill CA. Bronchioloalveolar carcinoma: a review. Radiology 1984;150:15-20.

7. Dodd GD, Boyle JJ. Excavating pulmonary metastases.Am J Roentgenol Radium Ther Nucl Med 1961;85:277-93.

8. Ohba S, Takashima T, Hamada S, Kitagawa M. Multiple cystic cavitary alveolar-cell carcinoma. Radiology 1972;104:65-6.

9. Weisbrod GL, Towers MJ, Chamberlain DW, Herman SJ, Matzinger FR. Thin-walled cystic lesions in bronchioalveolar carcinoma. Radiology 1992;185:401-5.

10.

10. Ryu JH, Swensen SJ. Cystic and cavitary lung diseases:focal and diffuse. Mayo Clin Proc 2003;78:744-52.

11.

11. Grant LA, Babar J, Griffin N. Cysts, cavities, and honeycombing in multisystem disorders: differential diagnosis and findings on thin-section CT. Clin Radiol 2009;64:439-48.

12.

12. Godwin JD, Webb WR, Savoca CJ, Gamsu G, Goodman PC. Multiple, thin-walled cystic lesions of the lung. AJR Am J Roentgenol 1980;135:593-604.

13.

13. Mahadeva R, Stewart S, Wallwork J. Metastatic endometrial stromal sarcoma masquerading as pulmonary lymphangioleiomyomatosis. J Clin Pathol 1999;52:147-8.

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논문 상세

Vol.68 No.2

다발성 낭성 유두상 폐선암 1예

A Case of Papillary Adenocarcinoma Presenting with Multiple Cysts

Abstract

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Tuberculosis & Respiratory Diseases