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Tuberculosis & Respiratory Diseases

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Vol.71 No.4
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Allergic Bronchopulmonary Aspergillosis Coupled with Sinusitis in a Nonasthmatic Patient

Tuberculosis & Respiratory Diseases / Tuberculosis & Respiratory Diseases,
2011, v.71 no.4, pp.278-281
Sung Woon Park (Chung-Ang University)

Jae Chol Choi (Chung Ang University)
Jae Yeol Kim (Chung Ang University)
In Won Park (Chung Ang University)
Byoung Whui Choi (Chung Ang University)
Sung, W. P. , Jae, C. C. , Jae, Y. K. , In, W. P. , & Byoung, W. C. (2011). Allergic Bronchopulmonary Aspergillosis Coupled with Sinusitis in a Nonasthmatic Patient. Tuberculosis & Respiratory Diseases, 71(4), 278-281.
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Abstract

Allergic bronchopulmonary aspergillosis (ABPA) is a complex clinical entity resulting from an allergic immune response to Aspergillus species, and most often occurs in patients with asthma. ABPA is rarely observed in the absence of asthma, which is, in fact, the principal criterion for its diagnosis. Our patient was a 53-year-old woman with no history of bronchial asthma. She presented with a 1-month history of cough, mucopurulent nasal discharge, and localized pulmonary consolidation. Peripheral blood eosinophilia and elevated serum IgE were observed. Sinus radiography showed right maxillary sinusitis. Pathologic examination of bronchoscopic biopsy specimens revealed conglomerates of fungal hyphae. Pulmonary function and bronchial provocation tests were within normal ranges. The patient was successfully treated for 3 months with itraconazole and oral prednisolone. There has been no evidence of recurrence over a 7-month follow-up. ABPA coupled with sinusitis in a nonasthmatic patient is a very rare occurrence and warrants reporting.

keywords
Aspergillosis, Allergic Bronchopulmonary, Sinusitis, Asthma

Reference

1.

1. Rosenberg M, Patterson R, Mintzer R, Cooper BJ, Roberts M, Harris KE. Clinical and immunologic criteria for the diagnosis of allergic bronchopulmonary aspergillosis. Ann Intern Med 1977;86:405-14.

2.

2. Kauffman HF. Immunopathogenesis of allergic bronchopulmonary aspergillosis and airway remodeling. Front Biosci 2003;8:e190-6.

3.

3. Slavin RG, Fischer VW, Levine EA, Tsai CC, Winzenburger P. A primate model of allergic bronchopulmonary aspergillosis. Int Arch Allergy Appl Immunol 1978; 56:325-33.

4.

4. Hoshino H, Tagaki S, Kon H, Shibusa T, Takabatake H, Fujita A, et al. Allergic bronchopulmonary aspergillosis due to Aspergillus niger without bronchial asthma. Respiration 1999;66:369-72.

5.

5. Berkin KE, Vernon DR, Kerr JW. Lung collapse caused by allergic bronchopulmonary aspergillosis in nonasthmatic patients. Br Med J (Clin Res Ed) 1982;285: 552-3.

6.

6. Koh WJ, Han J, Kim TS, Lee KS, Jang HW, Kwon OJ. Allergic bronchopulmonary aspergillosis coupled with broncholithiasis in a non-asthmatic patient. J Korean Med Sci 2007;22:365-8.

7.

7. Amin MU, Mahmood R. Multiple bronchoceles in a non-asthmatic patient with allergic bronchopulmonary aspergillosis. J Pak Med Assoc 2008;58:514-6.

8.

8. Greenberger PA, Patterson R. Allergic bronchopulmonary aspergillosis and the evaluation of the patient with asthma. J Allergy Clin Immunol 1988;81:646-50.

9.

9. Greenberger PA. Diagnosis and management of allergic bronchopulmonary aspergillosis. Allergy Proc 1994;15: 335-9.

10.

10. Shah A, Panchal N, Agarwal AK. Concomitant allergic bronchopulmonary aspergillosis and allergic Aspergillus sinusitis: a review of an uncommon association. Clin Exp Allergy 2001;31:1896-905.

11.

11. Shah A, Khan ZU, Chaturvedi S, Malik GB, Randhawa HS. Concomitant allergic Aspergillus sinusitis and allergic bronchopulmonary aspergillosis associated with familial occurrence of allergic bronchopulmonary aspergillosis. Ann Allergy 1990;64:507-12.

12.

12. Sher TH, Schwartz HJ. Allergic Aspergillus sinusitis with concurrent allergic bronchopulmonary Aspergillus: report of a case. J Allergy Clin Immunol 1988;81:844-6.

13.

13. Bhagat R, Shah A, Jaggi OP, Khan ZU. Concomitant allergic bronchopulmonary aspergillosis and allergic Aspergillus sinusitis with an operated aspergilloma. J Allergy Clin Immunol 1993;91:1094-6.

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