바로가기메뉴

본문 바로가기 주메뉴 바로가기

Tuberculosis & Respiratory Diseases

Article Contents

Prev Next
e-Submission

Vol.72 No.1
Citation Share

A Case of Primary Lung Cancer Producing Alpha-fetoprotein

Tuberculosis & Respiratory Diseases / Tuberculosis & Respiratory Diseases,
2012, v.72 no.1, pp.72-76






& (2012). A Case of Primary Lung Cancer Producing Alpha-fetoprotein. Tuberculosis & Respiratory Diseases, 72(1), 72-76.
  • Downloaded
  • Viewed
PDF Download

Abstract

We observed a very rare case of primary lung cancer producing alpha-fetoprotein (AFP). A 70-year-old male with a history of smoking 50 packs per year was diagnosed with large cell carcinoma of the lung. The clinical stage was T2bN3M0 (IIIB), and serum AFP was 23,247 ng/mL. There was no evidence of metastasis to the liver, scrotum or other organs. While undergoing chemotherapy for 1 year, as the cancer progressed the AFP value steadily increased. The patient died of respiratory failure due to pneumonia 12 months after being diagnosed with lung cancer.

keywords
alpha-Fetoproteins, Lung Neoplasms, Carcinoma, Large Cell

Reference

1.

1. Gitlin D, Perricelli A, Gitlin GM. Synthesis of -fetoprotein by liver, yolk sac, and gastrointestinal tract of the human conceptus. Cancer Res 1972;32:979-82.

2.

2. Ruoslahti E, Seppälä M. alpha-Fetoprotein in cancer and fetal development. Adv Cancer Res 1979;29:275- 346.

3.

3. Javadpour N. The National Cancer Institute experience with testicular cancer. J Urol 1978;120:651-9.

4.

4. Adachi Y, Tsuchihashi J, Shiraishi N, Yasuda K, Etoh T, Kitano S. AFP-producing gastric carcinoma: multivariate analysis of prognostic factors in 270 patients. Oncology 2003;65:95-101.

5.

5. Chang YC, Nagasue N, Kohno H, Taniura H, Uchida M, Yamanoi A, et al. Clinicopathologic features and long-term results of alpha-fetoprotein-producing gastric cancer. Am J Gastroenterol 1990;85:1480-5.

6.

6. O'Conor GT, Tatarinov YS, Abelev GI, Uriel J. A collaborative study for the evaluation of a serologic test for primary liver cancer. Cancer 1970;25:1091-8.

7.

7. Liebman HA, Furie BC, Tong MJ, Blanchard RA, Lo KJ, Lee SD, et al. Des-gamma-carboxy (abnormal) prothrombin as a serum marker of primary hepatocellular carcinoma. N Engl J Med 1984;310:1427-31.

8.

8. No EJ, Hur JW, Lee SS, Lee YM, Lee HP, Kim JI, et al. A case of alpha-fetoprotien producing adenocarcinoma of the lung. Tuberc Respir Dis 2006;61:70-3.

9.

9. Yasunami R, Hashimoto Z, Ogura T, Hirao F, Yamamura Y. Primary lung cancer producing alpha-fetoprotein: a case report. Cancer. 1981;47:926-9.

10.

10. Saka H, Sakai S, Kondo N, Ito M, Shimokata K. Successful resection of alpha-fetoprotein-producing lung cancer. Chest 1988;94:879-80.

11.

11. Kitada M, Ozawa K, Sato K, Matsuda Y, Hayashi S, Tokusashi Y, et al. Alpha-fetoprotein-producing primary lung carcinoma: a case report. World J Surg Oncol 2011;9:47.

12.

12. Hirota F, Hosaka K, Funahashi K, Oota M, Ikeda A, Oobayashi Y, et al. Effective treatment of AFP-producing lung cancer with UFT. Gan To Kagaku Ryoho 1999;26:381-4.

13.

13. Takahashi Y, Inoue T, Fukusato T. Protein induced by vitamin K absence or antagonist II-producing gastric cancer. World J Gastrointest Pathophysiol 2010;1:129- 36.

14.

14. Arnould L, Drouot F, Fargeot P, Bernard A, Foucher P, Collin F, et al. Hepatoid adenocarcinoma of the lung: report of a case of an unusual alpha-fetoprotein- producing lung tumor. Am J Surg Pathol 1997;21: 1113-8.

15.

15. Ishikura H, Kanda M, Ito M, Nosaka K, Mizuno K. Hepatoid adenocarcinoma: a distinctive histological subtype of alpha-fetoprotein-producing lung carcinoma. Virchows Arch A Pathol Anat Histopathol 1990; 417:73-80.

Tuberculosis & Respiratory Diseases

e-Submission OA Policy