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A Case of Pulmonary Blastomycosis Mimicking Pulmonary Tuberculosis

Tuberculosis & Respiratory Diseases / Tuberculosis & Respiratory Diseases,
2012, v.72 no.1, pp.77-81








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Abstract

Blastomyces dermatitidis is a dimorphic fungus that causes the systemic pyogranulomatous disease known as blastomycosis. Blastomycosis most often involves the lungs, skin, and may involve nearly every organ in the body. It is difficult, however, to diagnose blastomycosis in the early stage of pulmonary disease because clinical manifestations are varied from subclinical infection to acute respiratory distress syndrome. Since blastomycosis is often accompanied by granulomatous inflammation in histopathologic findings, differentiation from other etiologic diseases is important. We report a case of a 45-year-old male with pulmonary blastomycosis who had been misdiagnosed with tuberculosis for 3 months.

keywords
Blastomycosis, Granuloma, Tuberculosis

Reference

1.

1. Baumgardner DJ, Halsmer SE, Egan G. Symptoms of pulmonary blastomycosis: northern Wisconsin, United States. Wilderness Environ Med 2004;15:250-6.

2.

2. Sheflin JR, Campbell JA, Thompson GP. Pulmonary blastomycosis: findings on chest radiographs in 63 patients. AJR Am J Roentgenol 1990;154:1177-80.

3.

3. Mukhopadhyay S. Role of histology in the diagnosis of infectious causes of granulomatous lung disease. Curr Opin Pulm Med 2011;17:189-96.

4.

4. Gilchrist TC, Stokes WR. A case of pseudo-lupus vulgaris caused by a blastomyces. J Exp Med 1898;3:53-78.

5.

5. Smith JA, Kauffman CA. Blastomycosis. Proc Am Thorac Soc 2010;7:173-80.

6.

6. Dworkin MS, Duckro AN, Proia L, Semel JD, Huhn G. The epidemiology of blastomycosis in Illinois and factors associated with death. Clin Infect Dis 2005;41: e107-11.

7.

7. Koh JK. Clinicohistopathologic findings and their differential diagnoses of pathogenic fungal infections of cutaneoua deep mycoses. Korean J Med Mycol 1997;2: 101-9.

8.

8. Cho JH, Suh JS, Kim JH. Systemic blastomycosis with osseous involvement of the foot: a case report. J Korean Foot Ankle Soc 2005;9:216-9.

9.

9. Seo CG, Seo YW, Park HP, Choi WI, Beom HS, Kwon KY, et al. A case of blastomycosis after traveling around non-endemic area. Tuberc Respir Dis 2005;58: 619-23.

10.

10. Pappas PG. Blastomycosis. Semin Respir Crit Care Med 2004;25:113-21.

11.

11. Lee YB. Studies on the systemic mycosis in Korea and the special stainings for fungi. Korean J Med 1964;7: 523-43.

12.

12. Bialek R, Cirera AC, Herrmann T, Aepinus C, Shearn- Bochsler VI, Legendre AM. Nested PCR assays for detection of Blastomyces dermatitidis DNA in paraffinembedded canine tissue. J Clin Microbiol 2003;41: 205-8.

13.

13. Chapman SW, Dismukes WE, Proia LA, Bradsher RW, Pappas PG, Threlkeld MG, et al. Clinical practice guidelines for the management of blastomycosis: 2008 update by the Infectious Diseases Society of America. Clin Infect Dis 2008;46:1801-12.

Tuberculosis & Respiratory Diseases