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Tuberculosis & Respiratory Diseases

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Vol.73 No.6
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Sarcoidosis Presenting with Massive Pleural Effusion and Elevated Serum and Pleural Fluid Carbohydrate Antigen-125 Levels

Tuberculosis & Respiratory Diseases / Tuberculosis & Respiratory Diseases,
2012, v.73 no.6, pp.320-324












& (2012). Sarcoidosis Presenting with Massive Pleural Effusion and Elevated Serum and Pleural Fluid Carbohydrate Antigen-125 Levels. Tuberculosis & Respiratory Diseases, 73(6), 320-324.
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Abstract

A 55-year-old woman was admitted for an elevated serum carbohydrate antigen-125 (CA-125) level, and a left pleural effusion, which were detected at a routine health examination. Computed tomography of the chest was performed upon admission, revealing extensive bilateral paratracheal and mediastinal lymph node enlargement with a massive left-sided pleural effusion. Subsequent analysis of the pleural fluid demonstrated consistency with an exudate, no evidence of malignant cells, and a normal adenosine deaminase. However, the pleural fluid and serum CA-125 levels were 2,846.8 U/mL and 229.5 U/mL, respectively. A positron emission tomography did not reveal any primary focus of malignancy. Finally, a surgical mediastinoscopic biopsy of several mediastinal lymph nodes was performed, revealing non-necrotizing granulomas, consistent with sarcoidosis. After a month of treatment of prednisolone, the left pleural effusion had resolved, and after 2 months the serum CA-125 level was normalized.

keywords
Sarcoidosis, Pleural Effusion, CA-125 Antigen

Reference

1.

1. Huggins JT, Doelken P, Sahn SA, King L, Judson MA. Pleural effusions in a series of 181 outpatients with sarcoidosis. Chest 2006;129:1599-604.

2.

2. Kalluri M, Judson MA. Sarcoidosis associated with an elevated serum CA 125 level: description of a case and a review of the literature. Am J Med Sci 2007;334:441-3.

3.

3. Salerno D. Sarcoidosis pleural effusion: a not so common feature of a well known pulmonary disease. Respir Care 2010;55:478-80.

4.

4. Soskel NT, Sharma OP. Pleural involvement in sarcoidosis. Curr Opin Pulm Med 2000;6:455-68.

5.

5. Durand DV, Dellinger A, Guerin C, Guerin JC, Levrat R. Pleural sarcoidosis: one case presenting with an eosinophilic effusion. Thorax 1984;39:468-9.

6.

6. Cohen M, Sahn SA. Resolution of pleural effusions. Chest 2001;119:1547-62.

7.

7. Mansour M, Linden ER, Colby S, Posner G, Marsh F Jr. Elevation of carcinoembryonic antigen and CA-125 in a patient with multivisceral tuberculosis. J Natl Med Assoc 1997;89:142-3.

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