Sarcoidosis Presenting with Massive Pleural Effusion and Elevated Serum and Pleural Fluid Carbohydrate Antigen-125 Levels
박무석 (연세대학교)
김새별 (연세대학교)
문찬수 (연세대학교)
정성모 (연세대학교 의학과)
김송이 (연세대학교)
김은영 (연세대학교)
정지예 (연세대학교)
강영애 (연세대학교)
김영삼 (연세대학교)
김세규 (연세대학교)
장준 (연세대학교)
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Abstract
A 55-year-old woman was admitted for an elevated serum carbohydrate antigen-125 (CA-125) level, and a left pleural effusion, which were detected at a routine health examination. Computed tomography of the chest was performed upon admission, revealing extensive bilateral paratracheal and mediastinal lymph node enlargement with a massive left-sided pleural effusion. Subsequent analysis of the pleural fluid demonstrated consistency with an exudate, no evidence of malignant cells, and a normal adenosine deaminase. However, the pleural fluid and serum CA-125 levels were 2,846.8 U/mL and 229.5 U/mL, respectively. A positron emission tomography did not reveal any primary focus of malignancy. Finally, a surgical mediastinoscopic biopsy of several mediastinal lymph nodes was performed, revealing non-necrotizing granulomas, consistent with sarcoidosis. After a month of treatment of prednisolone, the left pleural effusion had resolved, and after 2 months the serum CA-125 level was normalized.
- keywords
- Sarcoidosis, Pleural Effusion, CA-125 Antigen
참고문헌
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